AbstractObjectives:The aim of this study was to evaluate the effect of a mild cognitive impairment (MCI) management program on traditional Korean medicine in a public health center.
Methods:In order to examine the effect of the MCI management program, we investigated MCI patients who participated in the program. MCI patients were treated with Jodeung-san (JDS) or Dangguijagyag-san (DGJYS) for 6 weeks. Mini Mental State Examination-Dementia Screening (MMSE-DS), Geriatric Quality of Life-Dementia (GQOL-D), Geriatric Depression Scale in Korea (GDS-K), and biochemical examination of blood were conducted at intervals of 6 weeks. A satisfaction survey was collected after this program.
Results:MMSE-DS mean score increased significantly, by 4.09 (p=0.000) in the JDS group and by 4.15 (p=0.000) in the DGJYS group. GQOL-D mean score also increased significantly, by 5.90 (p=0.000) in the JDS group and by 5.07 (p=0.000) in the DGJYS group. GDS-K mean score decreased significantly, by 10.63 (p=0.000) in the JDS group and by 9.69 (p=0.000) in the DGJYS group. MMSE-DS, GDS-K and GQOL-D scores were not significantly different between the JDS and DGJYS groups. All of the participants were satisfied with the program, and 90% of the participants expressed a high intention to participate in the program again.
References1.. Statistics Korea. Future Population Projection. Statistics Korea;2012.
2.. Ministry of Health & Welefare. Survey of Dementia Prevalence Rate. Ministry of Health & Welefare;2008.
3.. Ku BD, Kim SG, Lee JY, Park KH, Shin JH, Kim KK, et al. Clinical practice guideline for dementia by Clinical Research Center for Dementia of South Korea. J Korean Med Assoc. 2011; 54:8. 861–875.
4.. Choi KG. Neuropathology of MCI-View from Relationships with Aging and Alzheimer’s Disease-. Dementia and Neurocognitive Disorders. 2003; 2:101–107.
5.. Petersen RC, Doody R, Kurz , Mohs RC, Morris JC, Rabins PV, et al. Current Concepts in Mild Cognitive Impairment. Arch Neurol. 2001; 58:1985–1992.
6.. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Aging, memory, and mild cognitive impairment. Int Psychogeriatr. 1997; 9:1. 65–69.
7.. Shah Y, Tangalos EG, Petersen RC. Mild cognitive impairment. When is it a precursor to Alzheimer’s disease? Geriatrics. 2000; 55:65–68.
8.. Flicker C, Ferris SH, Reisberg B. Mild cognitive impairment in the eldery: predictiors of dementia. Neurology. 1991; 41:1006–1009.
9.. Ministry of Health & Welefare. National Epidemiologic Investigation. Ministry of Health & Welefare;2008.
10.. Han CS, Lee JY, Lee DW, Ryu SH, Lee KJ, Kim JH, et al. Development of Hybrid Model for Integrating Management of Geriatric Depression and Dementia in Urban Area. J Korean Geriatr So. 2006; 10:2. 104–114.
11.. John KA, Heather BB. The sensitivity of the Beck Depression Inventory to changes of symptomatology. Br J Psychiatry. 1974; 125:184–185.
13.. Heo EJ, Kang JS, Kang HW, Jeon WK. Evaluation on the Quality of Research Field with Traditional Herbal Prescriptions for Dementia Therapy. J of Oriental Neuropsychiatry. 2012; 23:1. 93–114.
14.. Murakami Y, Zhao Q, Harada K, Tohda M, Watanabe H, Matsumoto K. Choto-san, a Kampo formula, improves chronic cerebral hypo-perfusion-induced spatial learning deficit via stimulation of myscarinic M1 receptor. Pharmacology Biochemistry and Behavior. 2005; 81:3. 616–625.
15.. Koichi Y, Yutaka S, Etsuro H, Nobuyasu S, Hirozo G, Owao S, et al. Protective effects of Choto-san and hooks and stems of Uncaria sinesis against delayed neuronal death after transient forebrain ischemia in gerbil. Phytomedicine. 2004; 11:478–489.
16.. Watanabe H, Zhao Q, Matsumoto K, Tohda M, Murakami Y, Zhang SH, et al. Pharmacological evidence for antidementia effect of Chotosan(Guteng-san), a traditional Kampo medicine. Pharamacol Biochem Behav. 2003; 75:3. 635–643.
17.. Mizushima Y, Kan S, Yoshida S, Irie Y, Urata Y. Effect of Choto-san a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse(SAM). Phytotherapy research. 2003; 17:542–545.
18.. Matsuoka T, Narumoto J, Shibata K, Okamura A, Taniguchi S, Kitabayashi Y, et al. Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer’’s Disease. Evi-Based Com and Alt Med. 2012.
19.. Inanaga K, Dainoson K, Ninomiya Y, TAkii O, Omaru M, Tanaka T, et al. Effects of Toko-Shakuyaku-San in Patients with Senile Cognitive Disoreders. Progress in Medicine. 1996; 16:293–300. 1996.
20.. Iwasaki K, Satoh-Nakaqawa T, Maruyama M, Monma Y, Tomita N, Tanji H, et al. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symtoms and activities of daily living in dementia patients. J Clin Psychiatry. 2005; 66:2. 248–252.
21.. Folstein MF, Folstein SE. “Mini-Mental State”: a practical method for grading the cognitive state of patients for the clinician. J of Psych Res. 1975; 12:189–198.
22.. Park JH, Kwon YC. Standardization of Korean of the Mini-Mental State Examination (MMSE-K) for Use in the Elderly-Part II. Diagnostic Validity. J Korean NeuroPsychiatric Assoc. 1989; 28:508–513.
23.. Kang YW, Na DY, Han SH. A Validity Study on the Korean Mini-Mental State Examination (K-MMSE) in Dementia Patients. J Korean Neurol Assoc. 1997; 15:300–307.
24.. Lee JH, Lee KU, Lee DY, Kim KW, Kim JH, Lee KH, et al. Development of the Korean version of the consortium to establish a registry for alzheimer’s disease assessment packet (CERAD-K): clinical and neuro-psychological assessment batteries. J Gerontology Series B: Psychological Sciences and Social Sciences. 2002; 57:1. 47–53.
25.. Han JW, Kim TH, Joo JH, Park JH, Kim JR, Yoo SH, et al. A Normative Study of the Mini-Mental State Examination for Dementia Screening (MMSE-DS) and Its Short form (SMMSE-DS) in the Korean Elderly. J Korean Geriatr Psychiatry. 2010; 14:1. 27–37.
26.. Lee HS, Kim JH, Ko HJ, Ku HM, Kwon EJ, Shin JY, et al. The Standardization of the Geriatric Quality of Life scale-Dementia(GQOL-D). J Korean Geriatr Soc. 2004; 8:3. 151–164.
27.. Ki BS, Lee CW. A Preliminary Study for the Standardization of Geriatric Depression Scale in Korea. J Korean NeuroPsychiatric Assoc. 1995; 129:1875–1885.
28.. Ministry of Health & Welefare. Direction for Korean Medicine Health Promotion Program in 2013. Ministry of Health & Welefare;2012.
29.. Gyeonggi Statistical Information Service. Population Statistics. Gyeonggi Statistical Information Service;2012.
30.. Choi SH, Na DL, Oh KM, Park BJ. A Short form of the Samsung Dementia Questionnaire (S-SDQ): development and cross-validation. J Korean Neurol Assoc. 1997; 17:2. 253–258.
31.. Galasko D, Kauber MR, Hoftetter R, Salmon DP, Lasker B, Thal LJ. The mini-mental state examination in the elderly diagnosis of Alzheimer’ disease. Arch Neurol. 1990; 47:1. 49–52.
32.. Clark CM, Sheppard L, Fillenbaum GG, Galasko D, Morris JC, Koss E, et al. Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer’s Disease. Arch Neurol. 1999; 56:7. 857–862.
|
|