AbstractObjectivesThe present study aimed at investigating the effects of Schisandrae Fructus (SF) on menopause symptoms in ovariectomized mice.
Methods6 weeks old female mice were ovariectomized (OVX), and the OVX mice were fed with a three doses of SF (25, 100, and 400 mg/kg, respectively) or 17β-estradiol (E2, 0.5 mg/kg) 3 times a week for 6 weeks. Body weight was measured at every week and uterus weight was also measured at the end of experiment. Lipids and osteocalcin levels in serum were analyzed.
ResultsThe uterine weight was not changed in SF treated group, while E2 intake increased the reduced uterine weight by OVX. Although Body weight was increased since two weeks after ovariectomy compared with sham operated group, there was no change in SF or E2 treated group compared with OVX. But LDL was significantly reduced in SF (400 mg/kg) or E2 fed mice and SF or E2 treatment decreased enhanced osteocalcin level by OVX.
참고문헌1. Archer, DF, Sturdee, DW, Baber, R, de Villiers, TJ, Pines, A, & Freedman, RR, et al. Menopausal hot flushes and night sweats: where are we now? Climacteric, (2011). 14, 515-28.
2. Body, JJ. Calcitonin for the long-term prevention and treatment of postmenopausal osteoporosis. Bone, (2002). 30(5 Suppl), 75S-79S.
3. Ross, RK, Paganini-Hill, A, Wan, PC, & Pike, MC. Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin. J Natl Cancer Inst, (2000). 92(4), 328-32.
4. Ziel, HK. Estrogen’s role in endometrial cancer. Obstet Gynecol, (1982). 60, 509-15.
5. Nelson, HD, Humphrey, LL, Nygren, P, Teutsch, SM, & Allan, JD. Postmenopausal hormone replacement therapy: scientific review. JAMA, (2002). 288(7), 872-81.
6. Ahn, KH, Kim, SM, Yi, KW, Park, HT, Shin, JH, & Kim, YT, et al. The Effect of Pomegranate on Postmenopausal Syndrome: A Randomized, Double-blind, Placebo-controlled Trial. J Korean Soc Menopause, (2010). 16(2), 99-106.
7. Herbology Association of Korea’s Colleges of Oriental Medicine. Textbook of Herbology. Younglimsa, (2011). 683-684.
8. Koo, DC, Suh, WS, Baek, SY, & Shim, SH. Quantitative Determination of Lignans from Schizandra chinensis by HPLC. Kor J Pharmacogn, (2011). 42(3), 233-9.
9. Lee, Y, Lee, HS, Jang, SJ, & Song, JH. Effect of Water Extract of Schisandra Chinensis on Osteoclast Differentiation. Korean J Oriental Physiology & Pathology, (2010). 24(5), 848-53.
10. Lee, YJ, Cho, JY, Kim, JH, Park, WK, Kim, DK, & Rhyu, MR. Extracts from Schizandra chinensis Fruit Activate Estrogen Receptors: A Possible Clue to Its Effects on Nitric Oxide-Mediated Vasorelaxation. Biol Pharm Bull, (2004). 27(7), 1066-9.
11. Picherit, C, Coxam, V, Bennetau-Pelissero, C, Kati-Coulibaly, S, Davicco, MJ, & Lebecque, P, et al. Daidzein Is More Efficient than Genistein in Preventing Ovariectomy-Induced Bone Loss in Rats. J Nutr, (2000). 130(7), 1675-81.
12. So, H, Ahn, S, Song, R, & Kim, H. Relationships among Obesity, Bone Mineral Density, and Cardiovascular Risks in Post-menopausal Women. Korean J Women Health Nurs, (2010). 16(3), 224-33.
13. Garnero, P, Sornay-Rendu, E, Claustrat, B, & Delmas, PD. Biochemical Markers of Bone Turnover, Endogenous Hormones and the Risk of Fractures in Postmenopausal Women: The OFELY Study. J Bone Miner Res, (2000). 15(8), 1526-36.
14. Han, JH. Oriental Pharmacology. Euisungdang, (2004). 529-532.
15. Lee, JY, Lee, GY, Yang, CH, & Roh, SS. The study on chemical components and oriental medical effects of Schizandrae Fructus. J A OM, (2013). 13(2), 61-66.
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