The Literary Trends of Herbal Prescription Ukgan-san and its Application in Modern Traditional Korean Medicine

Ki-Ho Cho; Tae-Hun Kim; Chul Jin; Ji-Eun Lee; Seungwon Kwon; Cho, Ki-Ho; Kim, Tae-Hun; Jin, Chul; Lee, Ji-Eun; Kwon, Seungwon

doi:10.13048/jkm.18021

JKM > Volume 39(3); 2018 > Article

Cho, Kim, Jin, Lee, and Kwon: The Literary Trends of Herbal Prescription Ukgan-san and its Application in Modern Traditional Korean Medicine

Original Article

The Journal of Korean Medicine 2018; 39(3): 17-27.

Published online: September 30, 2018

DOI: https://doi.org/10.13048/jkm.18021

The Literary Trends of Herbal Prescription Ukgan-san and its Application in Modern Traditional Korean Medicine

Ki-Ho Cho¹, Tae-Hun Kim²

, Chul Jin¹

, Ji-Eun Lee¹, Seungwon Kwon¹

¹Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea

²College of Korean Medicine, Kyung Hee University Korean Medicine Clinical Trial Center, Kyung Hee University Korean Medicine Hospital, Seoul, Republic of Korea

Correspondence to: 권승원(Seungwon Kwon) 대한민국 서울 동대문구 경희대로23 Te: +82-02-958-9127, Fax: +82-02-958-9132, E-mail: kkokkottung@hanmail.net

Received August 22, 2018 Revised September 9, 2018 Accepted September 9, 2018

Abstract

Objectives

Ukgan-san does not appear in Traditional Korean Medicine classics. However, it has been used in research and clinical applications in Korea. In this paper, we are aiming to examine the records concerned with Ukgan-san to the present, and announce the present usage state in Korea.

Methods

We searched and summarized the contents of previous medical books about Ukgan-san. In order to investigate the current status of utilization of Ukgan-san in Korea, a bibliographic database of Korea, a database of clinical researches, and a database of pharmaceuticals of the Korea Food and Drug Administration were searched.

Results

As a result of searching Ukgan-san related documents, Ukgan-san has been developed in China (Ming dynasty). However, its clinical application has been expanded by modern Japanese kampo medicine doctors. In Korea, cases of Parkinson’s disease, other movement disorders, and psychiatric disorders have been reported, and randomized controlled trials had been done and planned. In addition, some extracts which are consisted of Ukgan-san are also available.

Conclusions

In Korea, Ukgan-san has been influenced by Japan and has been used for clinical and research purposes. The utilization rate in Korea is still small, but the utilization rate will increase according to the results of clinical studies.

Keywords: Ukgan-san, Yigan-san, Yokukansan, Literary Trend, Original text, Application

Table 1

Ukgan-san Related Records in the Previous Literature6–16)

Author 『Title』	Ukgan-san Realted Records
왕긍당 『증치준승』	『보영촬요』의 내용을 그대로 인용 “治肝經虛熱發搐或發熱咬牙或驚悸寒熱或嘔吐痰涎腹脹少食睡臥不安”
장개빈 『경악전서』	『보영촬요』의 내용을 그대로 인용 “治肝經虛熱發搐或發熱咬牙或驚悸寒熱或嘔吐痰涎腹脹少食睡臥不安”

후쿠이 후테이 『방독변해』	+ 대인, 소아 모두의 허증 간질에 활용할 수 있음을 언급

아사다 소하쿠 『물오약실방함구결』	+ 육억탕 (六抑湯) 인용 (억간산 -백출 복령 + 작약) + 가감억간산 제시 (억간산 – 천궁 + 반하 치자 황련 사초) + 사역산의 변방으로 간주하여 “좌측복직근긴장”을 처방목표로 제시 + 근맥구급 (筋脈强急)을 치료할 수 있음 제시 + 각종 경험 억간산가감방 제시

야가즈 도메이 『임상응용 한방처방해설』	+ 현대도량형에 맞춘 약물용량 제시 (백출 복령을 각 4.0g, 당귀 천궁 조구등 각 3.0g, 시호 2.0g, 감초 1.5g) + 구체적 적응증 제시 (간증 (癎症), 신경증, 신경쇠약, 히스테리, 밤마다 우는 아이, 불면, 수면 중 이갈이, 원인불명 열, 갱년기 장애, 여성생리와 관련된 증후, 틱, 뇌출혈 후유증, 신경성 사경 등) + 가감방으로 억간산가진피반하 공식적 등장!

오츠카 케이세츠, 야가즈 도메이, 시미즈 토타로 『한방진료의전』	+ 억간산가진피반하가 독립처방으로 제시됨 (출전 본조경험방 (本朝經驗方) 이라 함)

일약연한방전문위원회 『일반용 한방처방 매뉴얼』	+ 엑기스제의 용량 수록

일본신경학회 『파킨슨병치료가이드라인2011]』	+ 파킨슨병 환각, 망상에 대한 효과 검토 필요함 제시

일본한방생약제제협회 『신 일반용 한방처방 매뉴얼』	+ 원 구성약물인 백출 대신 창출도 사용 가능함 제시 + 억간산가진피반하의 적응증을 갱년기질환에 중점두어 제시 + 경험방 ‘억간산가작약황련’ 제시 + 억간산 vs 가미소요산 감별 포인트 제시 (억간산: 신겨증 증상이 자각적 타각적으로 드러남 가미소요산: 평상시 신경증이 밖으로 드러나지 않는 경향)

일본노년의학회 『고령자의 안전한 약물치료를 위한 가이드라인』	+ 고령 환자 치매의 양성 행동심리증상에 활용할 수 있는 한방약으로 제시

일본신경학회 『치매질환진료가이드라인2017』	+ 치매환자의 초조성 흥분, 환각, 망상에 유효하여 사용을 검토해볼 수 있는 약으로 제시

Table 2

List of Diseases that Reported Case Reports Related to Ukgan-san in Korean Academic Field17–28)

Parkinson’s disease and other movement disorders

- Parkinson’s disease
- Drug-induced Parkinsonism
- Dementia with Lewy’s bodies
- Chorea
- Hemifacial spasm
- Cerebral palsy (Dystonia)
- Restless leg syndrome

Psychiatric diseases

- Attention Deficit Hyperactivity Disorder (ADHD)
- Somatization disorder
- Tourette syndrome

Table 3

Approval and Production Status of Ukgan-san plus Banha Jinpi by Korean Pharmaceutical Companies35)

Pharmaceutical company	Product name	Indications, composition and dosage (g)	Production (KRW 1,000)
경진제약사	경진억간산가진피반하 엑스과립	허약한 체질로서 신경이 흥분되어 있는 사람의 다음 증상 : 신경과민, 불면증, 야제증(夜啼症, 어린이가 밤에 울고 보채는 증상 ), 감증(疳症, 어린이가 소화기의 기능장애로 몸이 여위는 병증 ) 1 포(3g) 중 당귀 1.0 조구등 1.0 천궁 1.0 백출 1.33 복령 1.33 시호 0.67 감초 0.5 진피 1.0 반하 1.67	2015년: 17,475 2017년: 11,098
한국인스팜(주)	인스팜억간산가진피반하 엑스과립		2012 년: 8,863 2013
한중제약(주)	한중억간산가진피반하 엑스과립		2013년: 3,665 2014년: 3,665 2015년: 3,696 2016년: 3,696 2017년: 3,696
천우신약(주)	경보나 (억간산가진피반하엑스과립)	허약한 체질로서 신경이 흥분되어 있는 사람의 다음 증상 : 신경과민, 불면증, 야제증(夜啼症, 어린이가 밤에 울고 보채는 증상 ), 감증(疳症, 어린이가 소화기의 기능장애로 몸이 여위는 병증 ) 1포 (5g) 중 당귀 1.0 조구등 1.0 천궁 1.0 백출 1.33 복령 1.33 시호 0.67 감초 0.5 진피 1.0 반하 1.67	생산실적자료없음
(주)한국신약	한신억간산가진피반하탕 엑스과립		생산실적자료없음
(유)한풍제약	한풍억간산가진피반하탕 엑스과립	허약한 체질로서 신경이 흥분되어 있는 사람의 다음 증상 : 신경과민, 불면증, 야제증(夜啼症, 어린이가 밤에 울고 보채는 증상 ), 감증(疳症, 어린이가 소화기의 기능장애로 몸이 여위는 병증 ) 1 포 (3g) 중 당귀 1.0 조구등 1.0 천궁 1.0 백출 1.33 복령 1.33 시호 0.66 감초 0.5 진피 1.0 반하 1.66	2012년: 25,377 2014년: 22,137 2015년: 13,051 2016년: 20,520
경방신약(주)	히스테엑스과립 (억간산가진피반하)	허약한 체질로서 신경이 흥분되어 있는 사람의 다음 증상 : 신경과민, 불면증, 야제증(夜啼症, 어린이가 밤에 울고 보채는 증상 ), 감증(疳症, 어린이가 소화기의 기능장애로 몸이 여위는 병증 ) 1 포 (2.5g) 중 당귀 1.0 조구등 1.0 천궁 1.0 백출 1.33 복령 1.33 시호 0.67 감초 0.5 진피 1.0 반하 1.67	생산실적자료없음

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