AbstractObjectivesThe aim of this review is to assess the clinical benefit of chuna for managing symptoms in chronic fatigue syndrome (CFS)
MethodsWe searched eligible studies from the following 11 databases with no language restriction: Pubmed, CENTRAL, Embase, CNKI, CQVIP, Wanfang, CiNii, OASIS, RISS and Koreamed. We selected randomized controlled trial (RCT), quasi-randomized controlled trial (Quasi-RCT) and controlled clinical trial (CCT) in which patients with chronic fatigue syndrome were treated with chuna. The results of the included studies were synthesized through meta-analysis, and their risk of bias were also assessed.
ResultsWe searched 914 potentially relevant studies, and only 20 studies were selected for this systematic review. Meta-analysis showed that chuna was more effective in improving general symptoms (n=291, RR 0.19 [95% CI 0.11 to 0.32], Z=6.08, p<0.00001, I2=0%), fatigue (n=487, SMD −0.95 [95% CI −1.19 to −0.71], Z=7.76, p<0.00001, I2=37%) and sleep disorder (n=139, SMD −0.58 [95% CI −0.92 to −0.24], Z=3.36, p=0.0008, I2=0%) compared to health supplements or usual care. When chuna was used as an added intervention, it was more effective in improving general symptoms(n=729, RR 0.25 [95% CI 0.15 to 0.42], Z=5.19, p<0.00001, I2=0%) and fatigue severity alone(n=217, SMD −1.21 [95% CI −1.53 to −0.89], Z=7.45, p<0.00001, I2=15%) compared to control.
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