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JKM > Volume 42(1); 2021 > Article
Jeon, Kim, and Son: Recovery of an Elderly Kwashiorkor Patient by Korean Medicine: A Case Report

Abstract

Objectives

The present study reports case of an elderly kwashiorkor patient who was treated with Korean Medicine.

Methods

A 68-year-old female patient with weight loss, general weakness, chills, anorexia, and dizziness after over 100 episodes of diarrhea visited the hospital. Blood tests showed hypoalbuminemia and anemia, and ultrasonography revealed fatty liver disease. The patient was diagnosed with kwashiorkor, and her symptom differentiation was Yang deficiency followed by Both Qi-Blood deficiency. Sayeok-Tang, Soshiho-Tang, Insamyangyeong-Tang, and Gongjin-Dan, herbal drugs, were given to the patient during 40 days of hospitalization.

Results

After 40 days of hospitalization, her symptoms were reduced, and the blood test results improved.

Conclusion

This case presents the therapeutic potential of Korean medicine in the treatment of kwashiorkor.

Fig. 1
Summary of clinical outcome and treatment course.
jkm-42-1-129f1.gif
Table 1
Composition of Drugs
Drug Composition (g*)
Gongjin-Dan Cervi Parvum Cornu (0.8), Angelicae Gigantis Radix (0.8), Corni Fructus (0.8), Moschus berezovskii Flerove (0.08), Apis mellifera Linné (2)
Sayeok-Tang Glycyrrhizae Radix et Rhizoma (6), Zingiberis Rhizoma (5), Aconiti Lateralis Radix Preparata (4)
Insamyanyeong- Tang Paeoniae Radix (24), Zingiberis Rhizoma Recens (24), Angelicae Gigantis Radix (12), Cinnamomi Cortex (12), Citri Unshius Pericarpium (12), Zizyphi Fructus (12), Ginseng Radix (12), Atractylodis Rhizoma Alba (12), Astragali Radix (12), Glycyrrhizae Radix et Rhizoma (12), Anemarrhenae Rhizoma (12), Rehmanniae Radix Preparata (9), Schisandrae Fructus (9), Saposhnikoviae Radix (9), Polygalae Radix (6)

* The indicated dose is weight of each herb for an adult during one day

Table 2
Course of Laboratory Test Results
Parameter Inpatient (week) Outpatient (week) Normal range

0 1 2 3 4 6 7 30
Total protein (g/dL) 5.6 5.7 6.1 6.2 6.7 6.5 - - 6.6–8.7
Albumin (g/dL) 1.9 1.8 2.5 2.7 2.7 2.8 - - 3.5–5.2
ALP (U/L) 149 123 99 78 81 83 - - 40–129
WBC (103/ul) 6.7 8.3 8.2 6.9 7.2 8.3 9.8 6.4 4.5–11.0
Eosinophil (%) 14.0 9.5 12.5 22.9 28.2 33.0 41.2 4.8 <5
Hemoglobin (g/dL) 10.5 9.6 8.7 8.8 9.7 9.9 10.4 11.7 12–16
IgE (IU/mL) 20955 - - - - 19376 - - <1000

ALP: alkaline phosphatase, WBC: white blood cell, IgE: Immunoglobulin E

References

1. De Onis M, Monteiro C, Akré J, Glugston G. The worldwide magnitude of protein-energy malnutrition: an overview from the WHO Global Database on Child Growth. Bull World Health Organ. 1993; 71:6. 703
pmid pmc

2. Lochs H, Allison SP, Meier R, et al. Introductory to the ESPEN guidelines on enteral nutrition: terminology, definitions and general topics. Clin Nutr. 2006; 25:2. 180–186.
crossref pmid

3. Cereda E, Pedrolli C, Klersy C, et al. Nutritional status in older persons according to healthcare setting: a systematic review and meta-analysis of prevalence data using MNA®. Clin Nutr. 2016; 35:6. 1282–1290.
crossref

4. Healthcare Biagdata Hub. health insurance review & assessment service. http://opendata.hira.or.kr/op/opc/olap4thDsInfo.do. Published 2019Accessed February 10, 2019.


5. Puntis JWL. Malnutrition in Developed Countries. Ann Nestlé (English ed). 2009; 67:2. 65–72.
crossref

6. Pennington CR. Disease-associated malnutrition in the year 2000. Postgrad Med J. 1998; 74:868. 65–71.
crossref pmid pmc

7. Béhar M, Viteri F, Bressani R, et al. Principles of treatment and prevention of severe protein malnutrition in childeren (kwashiorkor). Ann N Y Acad Sci. 1958; 69:5. 954–968.
crossref pmid

8. Longo DL, Fauci AS, Kasper DL, et al. Harrison’s Principles of Internal Medicine. 2012. Mcgraw-hill;New York: 2012.


9. Boirie Y, Morio B, Caumon E, et al. Nutrition and protein energy homeostasis in elderly. Mech Ageing Dev. 2014; 136:76–84.
crossref pmid

10. Omran ML, Morley JE. Assessment of protein energy malnutrition in older persons, part I: History, examination, body composition, and screening tools. Nutrition. 2000; 16:1. 50–63.
crossref pmid

11. Norman K, Pichard C, Lochs H, et al. Prognostic impact of disease-related malnutrition. Clin Nutr. 2008; 27:1. 5–15.
crossref pmid

12. Kuniaki H, Akihiko T, Tetsuya H, et al. Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin’yoeito Therapy: A Case Report. Front Nutr. 2018; 5:September. 3–6.
crossref pmid pmc

13. Ogawa-Ochiai K, Kawasaki K. Panax ginseng for frailty-related disorders: a review. Front Nutr. 2019; 5:140
crossref pmid pmc

14. Sasatani Y, Okauchi S, Ohara G, et al. Long-term maintenance of nutritional status with ninjinyoueito in terminal patients with chronic respiratory disease: Two case reports. Biomed Reports. 2020; 12:3. 121–124.
crossref

15. May T, Klatt KC, Smith J, et al. Choline supplementation prevents a hallmark disturbance of Kwashiorkor in weanling mice fed a maize vegetable diet: hepatic steatosis of undernutrition. Nutrients. 2018; 10:5. 653
crossref pmc

16. Fechner A, Böhme CC, Gromer S, et al. Antioxidant Status and Nitric Oxide in the Malnutrition Syndrome Kwashiorkor. Pediatr Res. 2001; 49:2. 237–243.
crossref pmid

17. van Zutphen T, Ciapaite J, Bloks VW, et al. Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol. 2016; 65:6. 1198–1208.
crossref

18. Saunders J, Smith T. Malnutrition: causes and consequences. Clin Med (Northfield Il). 2010; 10:6. 624
crossref

19. Frenk S. Metabolic adaptation in protein-energy malnutrition. J Am Coll Nutr. 1986; 5:4. 371–381.
crossref pmid

20. Coulthard GM. Oedema in kwashiorkor is caused by hypoalbuminaemia. Paediatr Int Child Health. 2015; 35:2. 83–89.
crossref pmid pmc

21. Okada R, Nakachi S, Inokuma S. The severity of peripheral blood eosinophilia indicates an eosinophilia-associated disease corresponding to its level. Allergol Int. 2016; 65:1. 112–114.
crossref pmid

22. Walker C, Kägi MK, Ingold P, et al. Atopic dermatitis: correlation of peripheral blood T cell activation, eosinophilia and serum factors with clinical severity. Clin Exp Allergy. 1993; 23:2. 145–153.
crossref pmid

23. Trzeciak M, Gleń J, Bandurski T, et al. Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis. Clin Exp Dermatol. 2011; 36:7. 728–732.
crossref pmid

24. Lai F, Zhou G, Mai S, et al. Sini Decoction Improves Adrenal Function and the Short-Term Outcome of Septic Rats through Downregulation of Adrenal Toll-Like Receptor 4 Expression. Evid Based Complement Alternat Med. 2018; 2018:5186158.
crossref

25. Uto NS, Amitani H, Atobe Y, et al. Herbal Medicine Ninjin’yoeito in the Treatment of Sarcopenia and Frailty. Front Nutr. 2018; 5:126
crossref pmid pmc

26. Hong SS, Lee J, Lee JS, et al. The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model. J Ethnopharmacol. 2015; 168:268–278.
crossref pmid

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