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JKM > Volume 43(2); 2022 > Article
Choi and Kim: A study on the current state of Korean medicine treatment in infertile women: an observational multi-center study protocol



The purpose of this study is to investigate the characteristics of female infertility patients who come to Korean medicine clinics and analyze the trends of Korean medicine treatment methods and the effects of female infertility by registry data.


We are recruiting study participants from Korean medicine hospitals and clinics. If female infertility patients come, we will ask them to register for this study. After enrollment, we will collect demographic information, treatment methods, pregnancy results, adverse events, and treatment costs.


First, we will analyze the characteristics of patients, the status of the use of Korean medicine treatment interventions, the cost status of Korean medicine infertility treatment, and the delivery characteristics of pregnant women after Korean medicine treatment. Second, we will analyze the effectiveness of Korean medicine treatment. The primary outcome is clinical pregnancy rate, and secondary outcomes are 12-week pregnancy maintenance rate, degree of dysmenorrhea and premenstrual syndrome, stress level, and health-related quality of life score.


This study is the first observational multi-center study in Korea for female infertility. By establishing the registry, we are creating a resource that contains patient-reported outcome measures for female infertility. The registry is expected to provide valuable data for developing Korean medicine Clinical practice guidelines for female infertility.

Table 1
The Schedule of the Trial
Days Screening Visit 1 Visit N After 3 months from Visit 1 The Last Day of Treatment
Informed consent form
Confirm inclusion/exclusion criteria
Vital signs
Demographics and medical history
Check medication changes
Check treatment history
Check pregnancy
Check menstrual history
Assess sexual intercourse frequency
Assess infertility stress degree
Assess health-related quality of life
Check adverse reaction
Check treatment methods
Assess the costs
Table 2
The Schedule of the Trial (When a Patient Become Pregnant)
Days Pregnancy Confirmation IUP 12 weeks After Delivery
Check pregnancy
Assess sexual intercourse frequency
Check medication and treatment changes
Check adverse reactions
Check pregnancy maintenance
Assess health-related quality of life
Assess infertility stress degree
Check treatment methods
Assess the costs
Check delivery

IUP: Intrauterine pregnancy


1. The Society of Korean Medicine Obstetrics and Gynecology. 2021. Korean medicine obstetrics & gynecology. Seoul: Euiseongdang;p. 169

2. Lee DN, Choi MS, Kim DI. 2014; Investigation of the current clinical result of korean medical treatment of infertility -in major university korean medicine hospitals and local korean medicine clinics participated in the research-. J Korean Obstet Gynecol. 27:4. 69–87. https://doi.org/10.15204/jkobgy.2014.27.4.069

3. Yang I, SIm CK, Kim KJ. 2013; Analysis of studies directed at elucidating sterility in korean medicine. Journal of Physiology & Pathology in Korean Medicine. 27:1. 26–33.

4. Park Y-S, Baek J-H. 2011; Influence of herbal medicine and acupuncture treatment on the pregnancy rate in infertile women before in vitro fertilization-embryo transfer. The Journal of Korean Medicine. 32:5. 25–40.

5. Choi S-J, Kim D-I, Yoon SH, Lim C-Y, Lee J-M, Choe C-M. 2021; Effectiveness and safety of korean medicine for treating women with unexplained infertility: A multi-center observational study. Integrative medicine research. 10:4. 100751 https://doi.org/10.1016/j.imr.2021.100751
crossref pmid pmc

6. Han K, Ha I-H, Lee J-H. 2017; Application of health care big data and necessity of traditional korean medicine data registry. Journal of Korean Medicine for Obesity Research. 17:1. 46–53. https://doi.org/10.15429/jkomor.2017.17.1.46

7. Sohn E-H, Kim B-J, Kim J-K, Bae J-S, Baek W-K, Suh B-C, et al. 2011; Establishment and perspective of the korean als registry. Annals of Clinical Neurophysiology. 13:2. 71–79.

8. So M-J, Lee Y-J, Kim S-H, Jang J-B, Hwang D-S, Kim D-I. 2017; Trends analysis of clinical studies on korean medicine for infertility. The Journal of Korean Obstetrics and Gynecology. 30:1. 42–55. https://doi.org/10.15204/jkobgy.2017.30.1.042

9. Park J-K, Kim KH. 2017; A survey on uncovered services in national health insurance of traditional korean medicine institution. SPKOM. 21:3. 43–50. https://doi.org/10.25153/spkom.2017.21.3.005

10. Chu H, Jang B-H, Lee E, Moon S. 2021; Combined korean medicine therapies in children with allergic rhinitis: A multi-center, observational explanatory registry trial: A study protocol. Medicine. 100:51. https://doi.org/10.1097/MD.0000000000028181
crossref pmid

11. Kim B-J, Shin B-C, Heo I, Lim K-T, Park IH, Hwang E-H. 2017; Clinical research of korean medicine and western medicine collaboration registry for low back pain: A pilot study protocol. Journal of Korean Medicine Rehabilitation. 27:3. 117–124. https://doi.org/10.18325/jkmr.2017.27.3.117

12. Ko Y, Jang B-H, Oh M-S, Shin B-C, Kim SJ, Cha Y-Y, et al. 2020; Korean medicine registry for low back pain: A study protocol for prospective observational multi-center study (klos). Integrative Medicine Research. 9:4. 100448 https://doi.org/10.1016/j.imr.2020.100448
crossref pmid pmc

13. Lee K-J, Oh M-S, Lee E-J, Shin B-C, Hwang E-H, Kim S-J, et al. 2019; Trends of korean medicine conservative treatment using low back pain patients registry data: Analysis of medical records of 7 korean medical hospital. Journal of Korean Medicine Rehabilitation. 29:3. 87–101. https://doi.org/10.18325/jkmr.2019.29.3.87

14. Kim N-H, Park S-H, Hwang D-S, Lee J-M, Lee C-H, Lee K-S, et al. 2013; Study on status survey in female infertility patients admitted to korean medicine hospital. The Journal of Korean Obstetrics and Gynecology. 26:2. 120–137. https://doi.org/10.15204/jkobgy.2013.26.2.120

15. Kim C, Kim D, Park M, Jang B, Jeong H, Cho J. 2018. The survey on infertile couples participating oriental infertility treatment programs supported by local governments. Sejong: Ministry of Health and Welfare, Division of Traditional Korean Medicine Policy.

16. Cho S-Y, Yoo J-E, Ahn S-Y, Park E-J. 2021; A study reporting the korean medicine treatment infertility support program in chungcheongnam-do in 2019. The Journal of Korean Obstetrics and Gynecology. 34:2. 142–156. https://doi.org/10.15204/jkobgy.2021.34.2.142

17. Kwon N-Y, Park Y-Y, Kim H-J, Lee D-N. 2018; A study on pattern identification of patients who participated in korean medical infertility support program of cheongju-city. The Journal of Korean Obstetrics and Gynecology. 31:4. 147–164. https://doi.org/10.15204/jkobgy.2018.31.4.147

18. Nam E-Y, Yoo S-J, Kim H-J. 2015; A study assessing support project of korean medical treatment in infertility in jecheon. The Journal of Korean Obstetrics and Gynecology. 28:2. 120–132. https://doi.org/10.15204/jkobgy.2015.28.2.120

19. Choi S-J, Kim D-I, Park J-K, Lee M-Y. 2019; A study assessing 2018 gyenggi-do korean medicine support project for subfertility. The Journal of Korean Medicine. 40:3. 76–86. https://doi.org/10.13048/jkm.19028

20. Park C-H, Park M-S, Kim H-S, Cha Y-Y, Kim S-J, Ko Y-S, et al. 2017; The exploratory analysis on the registry data of patients with low back pain applying correlation analysis method. Journal of Korean Medicine Rehabilitation. 27:4. 97–109. https://doi.org/10.18325/jkmr.2017.27.4.97

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