A Case Report of a Patient with Long COVID Complaining of Cough and Sore throat Treated with Hyunggaeyungyo-tang and Saengmaek-san

Chang-hwan Yu; Yu, Chang-hwan

doi:10.13048/jkm.22041

JKM > Volume 43(3); 2022 > Article

Yu: A Case Report of a Patient with Long COVID Complaining of Cough and Sore throat Treated with Hyunggaeyungyo-tang and Saengmaek-san

Case Report

The Journal of Korean Medicine 2022; 43(3): 204-210.

Published online: September 1, 2022

DOI: https://doi.org/10.13048/jkm.22041

A Case Report of a Patient with Long COVID Complaining of Cough and Sore throat Treated with Hyunggaeyungyo-tang and Saengmaek-san

Chang-hwan Yu

Daeso Branch office of Eumseong Public Health Center, Eumseong-gun, Republic of Korea

Correspondence to: 유창환, 57-16, Otae-ro, Daeso-myeon, Eumseong-gun, Chungcheongbuk-do, Republic of Korea, Daeso Branch office of Eumseong Public Health Center, tel: 043-871-2263, fax: 043-881-7032, E-mail: yuch3943@gmail.com

Received June 14, 2022 Revised August 9, 2022 Accepted August 16, 2022

Abstract

Objectives

The purpose of this case study was to report the clinical improvement of Long COVID(cough, sore throat) treated with Korean herbal medicine(Hyunggaeyungyo-tang and Saengmaek-san).

Methods

To assess the treatment outcomes, I used the Visual analogue scale(VAS) to evaluate sore throat degree, and Leicester Cough Questionnaire Korean version(LCQ-K).

Results

After treatments, cough and sore throat were significantly improved with VAS and LCQ-K.

Conclusion

The Korean herbal medicine was effective in the treatment of patient who suffers Long COVID. This study suggested the possibility of Korean herbal medicine treatment for Long COVID.

Keywords: Long COVID, Korean herbal medicine, Public Health Center

Fig. 1

Change of Leicester Cough Questionnaire Korean version(LCQ-K)

Fig. 2

Chang of Sore throat Visual analogue scale(VAS)

Table 1

The Composition of Hyunggaeyungyo-tang

Herbal name	Scientific name	Dose (mg)
白芷	Angelica Dahurica Root Soft Ext.	220
當歸	Angelica Gigas Root Soft Ext.	290.4
枳殼	Aurantii Fructus Immaturus Soft Ext.	545.6
柴胡	Bupleurum Root Soft Ext.	220
川芎	Cnidium Rhizome Soft Ext.	378.4
連翹	Forsythia Fruit Soft Ext.	220
梔子	Gardenia Fruit Soft Ext.	378.4
甘草	Licorice Soft Ext.	277.2
芍藥	Peony Root Soft Ext.	290.4
桔梗	Platycodon Root Soft Ext.	343.2
防風	Saposhnikovia Root Soft Ext.	316.8
荊芥	Schizonepeta Spike Soft Ext.	176
黃芩	Scutellaria Root Soft Ext.	519.2

Table 2

The Composition of Saengmaek-san

Herbal name	Scientific name	Dose (g)
人蔘	Ginseng Ext. Powder	1.33
麥門冬	Liriope Tuber Ext. Powder	2.67
五味子	Schisandra Fruit Ext. Powder	1.33

참고문헌

1. Ministry of Health and Welfare. Coronavirus (COVID-19). Republic of Korea;Latest Updates. Accessed June 3, 2022. Available from: http://ncov.mohw.go.kr/en/bdBoardList.do?brdId=16&brdGubun=161&dataGubun=&ncvContSeq=&contSeq=&board_id=

2. Ita K.2021; Coronavirus Disease (COVID-19): Current Status and Prospects for Drug and Vaccine Development. Arch Med Res. 52:1. 15–24. https://doi.org/10.1016/j.arcmed.2020.09.010

3. Ministry of Health and Welfare. 코로나 확진자 후유증 조사 추진 및 빅데이터 개방(3.31.목, 정례브리핑). Accessed June 8, 2022. Available from: http://ncov.mohw.go.kr/tcmBoardView.do?brdId=3&brdGubun=31&dataGubun=&ncvContSeq=6532&board_id=312&contSeq=6532

4. Groff D., Sun A., Ssentongo A.E., Ba D.M., Parsons N., Poudel G.R., et al2021; Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review. JAMA Netw Open. 4:10. e2128568–e2128568. https://doi.org/10.1001/jamanetworkopen.2021.28568

5. 国家中医药管理局办公室. 新型冠状病毒肺炎诊疗方案(试行第九版). Accessed June 8, 2022. Available from: http://www.gov.cn/zhengce/zhengceku/2022-03/15/content_5679257.htm

6. Pang W., Yang F., Zhao Y., Dai E., Feng J., Huang Y., et al2022; Qingjin Yiqi granules for post-COVID-19 condition: A randomized clinical trial. J Evid Based Med. 15:1. 30–38. https://doi.org/10.1111/jebm.12465

7. An X., Peng B., Huang X., Jiang H., Xiong Z., Zhang H., et al2022; Ludangshen oral liquid for treatment of convalescent COVID-19 patients: a randomized, double-blind, placebo-controlled multicenter trial. Chin Med. 17:1. 1–8. https://doi.org/10.1186/s13020-022-00602-x

8. Lee S., Park J., jae Lee Y., hyoung Kim S., Lee J.2021; A Case Report of Taeeumin with Post COVID-19 Syndrome. J Sasang Const Med. 33:4. 32–42. https://doi.org/10.7730/JSCM.2021.33.4.32

9. Lee S.W., Kim T.H., Lee E.J., Jung I.C., Park Y.C., Lee S.W., et al2022; A Case Report on a Patient with Late Complications of COVID-19 Complaining of Dyspnea Treated with Korean Medicine Pulmonary Rehabilitation. J Korean Med. 43:1. 171–179. https://doi.org/10.13048/jkm.22013

10. Han J.M., Jung I.C., Kang W., Kim S.S., Yeo Y., Park Y.C.2014; Reliability and validity of Leicester Cough Questionnaire Korean version. Chron Respir Dis. 11:3. 147–152. https://doi.org/10.1177/1479972314536206

11. CDC. Long COVID or Post-COVID Conditions. Accessed June 8, 2022. Available from: https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html

12. Hui K.P.Y., Ho J.C.W., chun Cheung M., chun Ng K., Ching R.H.H., ling Lai K., et al2022; SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo. Nature. 603:7902. 715–720. https://doi.org/10.1038/s41586-022-04479-6

13. Menni C., Valdes A.M., Polidori L., Antonelli M., Penamakuri S., Nogal A., et al2022; Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study. Lancet (London, England). 399:10335. 1618–1624. https://doi.org/10.1016/S0140-6736(22)00327-0

14. The society of Internal Korean Medicine. 2021. Clinical Practice Guideline of Korean Medicine-Common Cold. KOONJA;Available from: https://nikom.or.kr/nckm/module/practiceGuide/view.do?guide_idx=161&menu_idx=14

15. Bae H., Kang W., Park Y.2008; Effectiveness of a Yeonkyopaedok-san Extract in the Treatment of The Common Cold: Results of a Community-based, Double Blind, Randomized Placebo Controlled Trial. Korean J Orient Physiol Pathol. 22:1. 234–245.

16. The whole country a college of Orental medicine. The joint textbook publish commission compilatioin. 2011. Herbology. 2nd ed. Yonglimsa:

17. Park J.H., Hong S.U.2012; The Effects of Hyunggaeyungyo-tang of Suppression of iNOS Production on Mice with Allergic Rhinitis. J Korean Orient Med Ophthalmol Otolaryngol Dermatology. 25:1. 12–21. https://doi.org/10.6114/jkood.2012.25.1.012

18. Baek H.J., Lee B.J., Jung S.K., Jung H.J.2016; Retrospective Study of Patients with Cough Treated with Eunhwayeongyo-tang. J of Int Korean Med. 37:6. 961–77. https://doi.org/10.22246/jikm.2016.37.6.961

19. Spinou A., Birring S.S.2014; An update on measurement and monitoring of cough: what are the important study endpoints? J Thorac Dis. 6:Suppl 7. S728–S734. https://doi.org/10.3978/j.issn.2072-1439.2014.10.08

20. Wang B., Liu Y., Wang Y., Yin W., Liu T., Liu D., et al2020; Characteristics of Pulmonary Auscultation in Patients with 2019 Novel Coronavirus in China. Respiration. 99:9. 755–763. https://doi.org/10.1159/000509610

21. Arts L., Lim E.H.T., van de Ven P.M., Heunks L., Tuinman P.R.2020; The diagnostic accuracy of lung auscultation in adult patients with acute pulmonary pathologies: a meta-analysis. Sci Rep. 10:1. 7347 https://doi.org/10.1038/s41598-020-64405-6

22. National Institute for Korean Medicine Development. 2021. 2020 Korean Medicine Utilization Survey. Available from: http://www.koms.or.kr/board/researchReport/view.do?post_no=1611682menu_no=21