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JKM > Volume 43(4); 2022 > Article
Suh, Hong, Lee, Yoon, Lee, Chung, and Kim: Managing Mental Health during the COVID-19 Pandemic: Recommendations from the Korean Medicine Mental Health Center



The persistence and unpredictability of coronavirus disease (COVID-19) and new measures to prevent direct medical intervention (e.g., social distancing and quarantine) have induced various psychological symptoms and disorders that require self-treatment approaches and integrative treatment interventions. To address these issues, the Korean Medicine Mental Health (KMMH) center developed a field manual by reviewing previous literature and preexisting manuals.


The working group of the KMMH center conducted a keyword search in PubMed in June 2021 using “COVID-19” and “SARS-CoV-2”. Review articles were examined using the following filters: “review,” “systematic review,” and “meta-analysis.” We conducted a narrative review of the retrieved articles and extracted content relevant to previous manuals. We then created a treatment algorithm and recommendations by referring to the results of the review.


During the initial assessment, subjective symptom severity was measured using a numerical rating scale, and patients were classified as low- or moderate-high risk. Moderate-high-risk patients should be classified as having either a psychiatric emergency or significant psychiatric condition. The developed manual presents appropriate psychological support for each group based on the following dominant symptoms: tension, anxiety-dominant, anger-dominant, depression-dominant, and somatization.


We identified the characteristics of mental health problems during the COVID-19 pandemic and developed a clinical mental health support manual in the field of Korean medicine. When symptoms meet the diagnostic criteria for a mental disorder, doctors of Korean medicine can treat the patients according to the manual for the corresponding disorder.


The first case of coronavirus disease (COVID-19) in South Korea was reported on January 20, 20201). Initially, the outbreak of the novel coronavirus was expected to be similar to previous epidemics, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and was expected to end without a significant impact. However, the COVID-19 pandemic has included several large-scale waves and continues to persist. Although the pandemic appeared to end after vaccines were developed and distributed, it continues to persist owing to the constant mutation of the virus2).
Although the outbreak of an epidemic elevates stress levels across society, most people return to their daily routines without psychological sequelae. For example, a survey conducted two years after the SARS outbreak indicated no significant increase in the prevalence of mental disorders3). However, the impact of the COVID-19 outbreak differs from that of previous epidemics. Compared to other infectious diseases, COVID-19 has spread to more countries, has had a greater impact on daily life, and has had significantly larger financial and occupational impacts4). Additionally, unlike other coronaviruses, COVID-19 exhibits a pattern similar to that of influenza, with a high infection rate, a relatively low fatality rate, and asymptomatic infection5). Furthermore, compared with previous diseases, COVID-19 has infected more people, and a greater number of medical professionals have been exposed to it. Owing to the prolonged duration of the pandemic, its long-term effects remain unknown3). Finally, uncertainty regarding vaccine effectiveness and the possibility of endless social distancing cause considerable psychosocial stress6).
Moreover, COVID-19 has produced social issues, such as social distancing, quarantine, isolation, and financial problems, which can wreak havoc on mental health. In general, the most crucial factors facilitating full recovery after a tragic event are social support and community solidarity. Individuals commonly experience depression and loneliness after a disaster7). In a community with a solid social foundation, a pandemic such as COVID-19 may cause individuals to experience high levels of loneliness 8). On the other hand, a sudden disaster leads individuals to realize their mortality and rely on familiar social support systems (e.g., marriage and religion) to cope with their fear of the unpredictable9). However, social distancing, quarantine, and isolation have rendered these countermeasures unavailable, thereby forcing individuals to independently solve many difficulties and highlight the importance of self-management10).
The current COVID-19 pandemic is affecting the mental health of not only patients, but their neighbors and the general population as well3,11,12). Consequently, unprecedented mental symptoms such as COVID Blue and COVID Red have emerged in public. However, clinicians still diagnose a general psychiatric disorders (e.g., major depression, anxiety disorders, or stress-related disorders) and only categorical treatment is provided for this condition1316). Increases in the prevalence of depression, anxiety, and anger throughout society continue to affect both primary healthcare and specialized medical institutions. Additionally, the impact of COVID-19 on mental health is often concomitant with emotional, cognitive, and somatic symptoms, such as sleep disorders and fatigue17,18), thus requiring an integrative approach for both the mind and body.
Social policies such as social distancing and quarantine have highlighted the importance of telemedicine and self-management10). The Association of Korean Medicine has consequently established telemedicine centers for confirmed COVID-19 cases19,20). The Korean Medicine Mental Health (KMMH) center developed the “2020 Mind training manual for doctors of Korean medicine at COVID-19 treatment sites” [informally published work] as a reference for doctors providing mental health support at telemedicine centers. The manual was approved for use in the field in the form of telemedicine for patients’ mental health by the Association of Korean Medicine20,21).
The major intervention of the manual was meditation, one of the mind-body modalities. The benefit of meditation on mental health was confirmed by several systematic reviews (e.g., depression22,23), anxiety24,25), posttraumatic stress disorder (PTSD)26), stress2729), and sleep quality30)). Therefore, meditation was widely recommended in clinical practice guidelines of Korean medicine for mental disorders such as depression31), anxiety disorders including PTSD 32), insomnia33), and Hwabyung (anger syndrome in Korean culture)34). Besides, meditation is essential and basic intervention for survivors of disasters. Thus, it is also recommended in a manual for disaster medical support using Korean medicine for disaster survivors35) and suggested during the COVID-19 pandemic3638).
As COVID-19 continues to persist for an extended period, individuals who have recovered from COVID-19 and non-confirmed individuals often visit primary clinics with complaints of mental health problems. However, to date, there are no clear guidelines how doctors of Korean medicine provide self-management for mental health to the patients in the context of the COVID-19 pandemic. Therefore, in order to update the previous manual (i.e., 2020 Mind training manual for doctors of Korean medicine at the COVID-19 treatment sites [informally published work]), we narratively reviewed other published review articles and manuals.


1 Research Team Composition

This manual was developed by researchers at the KMMH center, who previously participated in the development of the “Mind training manual for doctors of Korean medicine at COVID-19 treatment sites” in 202021). Two researchers (SYC and JWK) who participated in the development of the updated manual were professors of neuropsychiatry at Kyung Hee University Korean Medicine Hospital in Gangdong. Moreover, they are members of the Korean Society of Meditation and are R-level meditation instructors. Thus, the Neuropsychiatry Department of the Kyung Hee University Korean Medicine Hospital at Gangdong continues to use mind-body interventions such as mindfulness-based stress reduction (MBSR) and meditation for patients who visit the hospital. To assist in developing the manual, the first author (HWS) participated as a methodologist. To reflect on the medical field, two researchers (SH and HWL) participated as employees of Korean medicine hospitals. On the other hand, to reflect on the primary medical field, one researcher (ML), a general practitioner of Korean medicine working at a primary clinic, also participated in development process. In addition, another researcher (SIY) participated as an expert in psychology to provide advice on mind-body modalities.
The draft of the updated manual was written by HWS and SH. Then, the others independently read and critically reviewed the draft. We held informal meetings twice, and revised the draft to reflect all researchers’ opinion.

2 Narrative Review

A selective literature search method was adopted to examine the latest trends and expert perspectives on mental health during the COVID-19 pandemic. Among articles published before June 1, 2021, we conducted a keyword search using the terms “COVID-19” and “mental health.” For a rapid review, we limited the search database to MEDLINE (via PubMed), omitting gray literature. The study designs were limited to meta-analyses, reviews, and systematic reviews, to examine only the latest trends and expert knowledge (Supplementary Table 1).
Four researchers (HWS, SH, HWL, and ML) reviewed the titles and abstracts of the searched articles and excluded articles unrelated to COVID-19 and mental health issues. The two researchers (SH and HWL) read the full-text of the article, and excluded articles on topics that were irrelevant to the manual. Then, we classified the selected articles according to their themes. For articles with overlapping themes, we extracted subthemes based on the consensus of the two researchers after selecting articles through discussion.
Next, we selectively searched, selected, and reviewed previous manuals. The materials to review were as follows: 2020 Mind training manual for doctors of Korean medicine at the COVID-19 treatment sites [informally published work], psychological support guideline for the novel coronavirus developed by the National Center for Disaster and Trauma1), and manual for disaster medical support using Korean medicine for disaster survivors35).

3 Development and Endorsement of the Manual

To reflect the latest trends and expert perspectives on mental health, the data extracted from the narrative review were added to the previously developed manual. During the update process, we did not focus on trauma-induced mental disorders such as acute stress disorder and PTSD, which were previously prioritized by other manuals1), but instead focused on emotional symptoms such as anger, depression, and anxiety. Additionally, we aimed to further describe related symptoms, particularly stress responses concomitant with somatization, which do not meet the diagnostic criteria for a mental disorder for which Korean medicine is advantageous. Finally, based on the data collected by the research team, we created an algorithm and manual to improve usability in the primary clinical field of Korean medicine. Thereafter, we submitted our draft to the Society of Korean Medicine Neuropsychiatry for receiving endorsement.


1 Previous Reviews

In the first round, we identified 500 articles. We excluded one duplicate article and 159 articles unrelated to COVID-19 or mental health. Thus, we conducted an initial analysis of 340 articles related to this study’s theme based on content analysis (Figure 1).
In this study, we reviewed three categories: (i) causes of psychiatric problems during the COVID-19 pandemic, (ii) psychiatric symptoms and disorders during the COVID-19 pandemic, and (iii) therapeutic approaches to mental health during the COVID-19 pandemic.

1) Causes of Psychiatric Problems during the COVID-19 Pandemic

We extracted factors as “causes of psychiatric problems during the COVID-19 pandemic” as follows: personal factors3941), direct correlation to the virus4244), and social factors4548) (Table 1).
“Personal factors” included age, sex, marital status, educational level, housing, income, employment status, underlying diseases, history of mental illness (e.g., cognitive disorders, emotional or behavioral disorders, or other mental disorders), coping mechanisms, personal protective measures, perceived chances of survival, and weak solidarity with others. “Factors directly correlated to the virus” included direct or close contact with infected individuals and infected family members or friends. “Social factors” included COVID-19-related news in mainstream or social media, national policy, isolation (social distancing and quarantine), stigma, psychological support, and medical system. In particular, we were more concerned about children and adolescents, older adults, women (pregnant and postnatal), psychiatric patients with preexisting conditions4956), people who work at public sites, healthcare workers5760), day laborers, foreign workers, immigrants, and victims of domestic violence6165).
Based on these results, we decided to switch classification criteria from quarantine status to vulnerability and risk of symptom severity.

2) Psychiatric Symptoms and Disorders during the COVID-19 Pandemic

We extracted and categorized the subthemes of “psychiatric symptoms and disorders during the COVID-19 pandemic” as follows: spectrum of psychiatric symptoms and disorders66), emotional disturbance6771), somatization17,18), and reactions to external stimuli72,73) (Table 2).
As the subthemes of “spectrum of psychiatric symptoms and disorders,” we extracted the following: a new episode of mental breakdown in case of a patient predisposed to major mental disorders, rapid exacerbation in patients with preexisting disorders, occurrence of disorders related to trauma or stress factors (e.g., acute stress disorder, PTSD, and adjustment disorder), and psychiatric symptoms associated with stress responses that do not meet the diagnostic criteria for mental disorders. Psychiatric disorders closely related to COVID-19 infection or the COVID-19 pandemic are as follows: substance use disorder74,75), schizophrenia76), personality disorders77), obsessive compulsive disorder78), PTSD79,80), anxiety disorders81), cognitive disorders (e.g., dementia)82,83), panic disorder84), bipolar disorder85), suicide86,87), eating disorders88), and sleep disturbance8991). For “emotional disturbance,” subthemes were extracted based on related emotions. We extracted three subthemes regarding anxiety and fear: anxiety disorder, panic disorder, and PTSD. Regarding anger, we extracted subthemes of hypersensitivity, impulsiveness, addiction, and intemperance. Regarding depression, we extracted the following subthemes: guilt, boredom, pessimism, low self-esteem, and suicide. We extracted sleep disturbance, hyperarousal, fatigue, and exhaustion as the subthemes of “somatization.” Domestic violence, discrimination, and xenophobia were extracted as subthemes of “reactions to external stimuli.”
Through this narrative review, we recognized the various aspects of mental problems that the patients and general population experienced during the COVID-19 pandemic. Therefore, we suggested five types that could reflect these findings beyond the major psychiatric disorders: tension (a state of mixed anxiety, anger, and depression), anxiety-dominant, anger-dominant, depression-dominant, and somitization. At the same time, we decided that it is important to have doctors of Korean medicine screen for serious mental illness and to notice them that professional treatment or referral is necessary if suspected.

3) Therapeutic Approaches to Mental Health during the COVID-19 pandemic

We extracted and categorized the subthemes of “therapeutic approaches to mental health during the COVID-19 pandemic” as follows: personal care9297), remote medical treatment98103), medication treatment1316), and herbal medicine treatment104,105) (Table 3).
The subthemes of “personal care” were healthy living, regular exercise, balanced nutrition, good sleep, outdoor and physical activity, routinized daily life, improved resilience, strong bonds with people, solidarity with others, individual religious practices, psychotherapy such as mindfulness, community-based art therapy programs, and cultural interventions. We identified remote counseling, group-based cognitive behavioral therapy, psychological emergency care, and bibliotherapy as subthemes of “remote medical treatment.” As subthemes of “medication treatment,” we found that psychotropic drugs were used for COVID-19 patients and calcium channel blockers were used for dementia patients. In relation to COVID-19, we concluded that it was impossible to derive evidence-based recommendations for the use of psychotropic medication. We identified the subthemes of “herbal medicine treatment” as follows: the use of Lily bulb and Rehmannia decoction and Guilu Erxian decoction for PTSD; Suanzaoren decoction, Huanglian Ejiao decoction, and Zhizi Chi decoction for anxiety; Lily bulb and Rehmannia decoction, Lily bulb and Anemarrhenae decoction, and Ganmai Dazao decoction for depression.
We were able to confirm that personal care was recommended in addition to remote medical treatment, medication treatment (western medicine), and herbal medicine treatment from the existing evidence.

2. The Previous Manuals for Mental Health during the COVID-19 Pandemic or after a Disaster

We reviewed two previous manuals1,35) and compared the scales for assessment and evaluation.
Both manuals commonly recommended the following scales.
  • Numerical rating scale (NRS) or Subjective Units of Disturbance scale (both ranged from 0 to 10)

  • P4-Suicide-Risk-Screener106)

  • Primary care PTSD screen (PC-PTSD)107)

  • Patient Health Questionnaire-9 (PHQ-9)108111)

  • Generalized Anxiety Disorder-7 (GAD-7) 112114)

  • Patient Health Questionnaire-15 (PHQ-15)115119)

Clinical global impression-severity is only recommended in the psychological support guideline for the novel coronavirus developed by the National Center for Disaster and Trauma1). On the other hand, mental disorder-specific measurements are only addressed in the manual for disaster medical support using Korean medicine for disaster survivors35).
Among these scales, we adopted NRS, P4-Suicide-Risk-Screener, PC-PTSD, PHQ-9, and GAD-7 for essential scales, and adopted clinical global impression-improvement (CGI-I) for re-assessment tools.

3. Field Manual of Korean Medicine for Mental Health Support during the COVID-19 Pandemic

The manual was developed to provide support for medical institutions of Korean medicine (e.g., Korean medicine clinics, Korean medicine hospitals, and public medical institutions) to assess and categorize patients experiencing psychiatric or mental health problems during the epidemic period of infectious diseases such as COVID-19. This manual can be applied to the general population, healthcare workers, close contacts, confirmed patients, fully recovered patients, friends, and families.
The manual consists of three big steps and eight small steps. Small steps are formed as follows: Initial Assessment, Vulnerable Group Screening, Suicidal Risk Screening, Mental Health Screening, Type Assessment, Korean Medicine Interventions for Symptoms, Self-management and Evaluation of Treatment Effects. The first big step is a process to identify at-risk patients, diagnose high-risk groups and transfer them to specialists. First big steps consist of Initial Assessment, Vulnerable Group Screening and Suicidal Risk Screening. Second big step is a process for diagnosing mental illness. If the patient is better diagnosed with a mental illness, it is more effective to follow the previously developed manual for mental illness rather than this Manual. This step consists of Mental Health Screening. Last big step consists Type Assessment, Korean Medicine Interventions for Symptoms, Self-management and Evaluation of Treatment Effects. This step is to properly classify according to necessary treatments and treat the patient.
Figure 2 presents overview of development of the manual. Figure 3 presents an overview of the clinical pathways involved. The key recommendations for mental health evaluation are summarized in Table 4.

1) Initial Assessment

For the patients’ initial assessment, NRS was used for rapid risk evaluation. The level of pain experienced by the patient was expressed on a scale of 0–10, with 10 indicating unbearable pain and 0 indicating no pain. A score of 4 or below with no significant functional abnormalities was considered to indicate low risk. A score of 5 or higher affecting the functionality is considered moderate to high risk, which requires medical intervention. Emergency psychiatric screening was recommended when necessary. A neuropsychiatric referral should be made when a patient is deemed emergency patient120).

2) Vulnerable Group Screening

Even low-risk patients should be screened to determine vulnerability. When a patient is found to be susceptible, they can be classified as moderate-to-high risk and given a treatment suitable for the moderate-to-high risk group at the doctor’s discretion, even if the patient’s case is normal or mild.

(1) Low Risk of Severity

While some patients reporting neuropsychiatric symptoms due to the impact of COVID-19 require formal neuropsychiatric treatment, most people benefit from supportive interventions (e.g., mental health education and relaxation therapy) to improve health or resilience to stress. For patients experiencing normal-to-mild neuropsychiatric symptoms, it is possible to stabilize them by providing them with mental health education and by explaining that their neuropsychological symptoms are common responses to an infectious disease pandemic and that human beings have the ability to respond to stress in even more severe situations121). Additionally, doctors of Korean medicine, as well as social and mental health services, can introduce a method of managing and coping with stress (e.g., healthy lifestyle, routinized daily life, solidarity with others, and psychological therapy such as mindfulness)9297). When necessary, a doctor can advise patients to seek professional assistance. For self-care, doctors can utilize relaxation therapy, which includes breathing techniques, mindful breathing, and walking meditation120).

(2) Moderate-High Risk of Severity

Even among patients with normal-to-mild psychiatric symptoms, individual resilience is reduced if stress factors persist, making it difficult for them to return to normal daily life. Ongoing stress exacerbates existing psychiatric or psychological problems among vulnerable individuals, and can cause new psychiatric symptoms among healthy individuals. Persistent fear caused by COVID-19 and a lack of belief that the pandemic will be resolved can lead to anxiety, depression, and anger. Continuous tension induced by the external environment can perpetuate and solidify temporary somatic symptoms such as sleep disturbance and fatigue. These symptoms require management through appropriate interventions and mental relaxation 121). Groups that are more vulnerable to pandemic-related psychosocial stressors include people with illnesses, risk factors (children/adolescents, older adults, women, and people in regular contact with the public), preexisting psychiatric issues, and healthcare workers4960). For the general population, if psychiatric symptoms are severe or persist for an extended period, doctors can utilize medication1316), herbal medicine104,105), supportive counseling, and psychotherapy (e.g., remotely conducted mind-body intervention and problem-solving strategy)98103). It is essential to consider vulnerable patients during treatment and apply a multidisciplinary approach, depending on disease severity and comorbidity121).

3) Suicidal Risk Screening

The P4-Suicide-Risk-Screener106) was used to screen psychiatric emergency situations, such as suicide risk and self-harm.

4) Mental Health Screening

The following screening tools can be used to screen for significant mental conditions: PC-PTSD107), PHQ-9108111), GAD-7112114), and Hwabyung scale122). Critical cases such as trauma-induced mental disorders (acute stress disorder and PTSD), cognitive disorders, and psychiatric disorders should be categorized separately as significant mental conditions and addressed using traditional treatments. These cases require appropriate treatment in accordance with the previously developed clinical practice guidelines for Korean medicine.

5) Type Assessment

The COVID-19 pandemic has persisted for over two years and has shown long-term effects. To provide a suitable self-care guide, doctors of Korean medicine should categorize patients into the following groups: tension, anxiety-dominant, anger-dominant, depression-dominant, and somatization (Table 5).
The Mibyeong index (MBI) is used to classify the types. The MBI was designed to assess the health status of healthy and subclinical populations123). This instrument measures the severity, duration, and resilience of physical symptoms such as fatigue, pain, sleep disturbance, indigestion, and mental distress, including anxiety, anger, and depression.
Tension types may report ambiguous or sensitive physical or emotional symptoms. Other types of patients may also report specific symptoms. For example, the anxiety-dominant type is related to palpitations and chest discomfort; the anger-dominant type is related to irritability, hypersensitivity, addiction, chest pain, headache, and fever; the depression-dominant type is related to decreased interest, loss of appetite, lethargy; and the somatization type is related to physical symptoms (e.g., sleep disturbance, fatigue, and pain).

6) Korean Medicine Interventions for Symptoms

When a significant disorder is present, the patient is treated using existing traditional treatment. When a clear diagnosis cannot be made, despite the presence of various psychological and physical symptoms, treatment should focus on the most dominant symptom.

7) Self-management

For patients who visit medical institutions of Korean medicine, self-management methods such as relaxation and meditation can be taught for each symptom (Table 6).
The relaxation method is a part of the mind-body intervention method and refers to a technique for reducing physiological and psychological stress. Relaxation methods include deep breathing, breathing exercises, progressive muscle relaxation, autogenic training, relaxation using biofeedback, guided imagery, and self-hypnosis. Meditation is a well-established oriental practice that assists in the management of psychological symptoms, such as depression, anger, anxiety, and fear. While a therapist can perform meditation with a patient, it has the advantage that the patient can do so on his or her own after learning the technique. Meditation techniques vary, but one common goal is to relax the body, realize the suppressed self, and awaken senses while focusing on breathing. Using this technique, patients can experience the effects of physical relaxation, emotional control, and sedation. The principles and methods of autogenic training, relaxation exercises, and Qigong’s breathing technique are similar to those of meditation. Recently, an MBSR program was developed based on mindfulness, which is the core principle of Vipassanā or meditation120).

8) Evaluation of Treatment Effects

At the patient’s follow-up visit, the NRS was used again to check the level of improvement. For a more precise evaluation, MBI and CGI-I can be used. The validated scales for measuring symptom severity are summarized in Table 4.

4. Endorsement

The Society of Korean Medicine Neuropsychiatry operates a clinical practice guideline review committee. The committee reviews and endorses not only evidence-based clinical treatment guidelines but also manuals that can be used in the field. The committee consists of a total of 6 members, separate from the society’s executives, and each member independently reviews the submitted clinical guidelines or manuals based on the society’s criteria and decides whether to endorse or not through a meeting.
The criteria of the Society are as follows.
  • Is this guideline (manual) consistent with the purpose and direction of the society?

  • Has this guideline (manual) systematically reviewed the available evidence?

  • Are the guidelines presented in this guideline (manual) clearly described?

  • Did the guide presented in this guideline (manual) take the user’s point of view into consideration?

  • Are the guidelines presented in this guideline (manual) suitable for application to the target patient?

  • Will the benefits outweigh the harm to the patient if these guidelines (manuals) are followed?

  • After the society’s review, we received an endorsement from the Society of Korean Medicine Neuropsychiatry on June 30, 2022.


Although the COVID-19 pandemic has induced many types of neuropsychological distress, no definitive evidence-based manuals have been identified for these symptoms and illnesses. Psychiatric symptoms (e.g., depression, anxiety, anger, sleep disturbance, and stress disorder) are predictable symptoms that can develop when an infectious disease spreads or social distancing or lockdown is implemented10). The most important approach during a pandemic is the psychological approach, not the medication approach; thus, the use of medication should be minimized124,125). Thus, this manual was developed out of urgency for guidelines to promote self-management in patients visiting medical institutions of Korean medicine who report neuropsychological symptoms related to the COVID-19 pandemic. To update the manual, we conducted narrative reviews and reached informal consensus. Based on these results, we submitted the draft of this manual, and received endorsement of the Society of Korean Medicine Neuropsychiatry.
From the aforementioned perspective, this manual emphasizes psychological education, mind-body intervention, and psychotherapy in the treatment approach. The strength of Korean medicine is that it provides both preventive measures and mind-body interventions. This manual aims to screen low-risk patients through risk assessment, so that doctors of Korean medicine can boost individual patients’ resilience by focusing on psychological health education and self-management methods to understand and manage their symptoms, even without direct medical intervention that utilizes medication or psychotherapy. In the meantime, vulnerable groups are screened so that doctors of Korean medicine can provide suitable treatments and interventions for low-risk patients who require help. Therefore, this manual systematically classifies participants and respects the self-recovery of individual patients. Psychological training and self-management methods were highlighted for patients who did not require medication or in-depth psychotherapy. For moderate-high-risk patients who required treatment, we aimed to implement adequate management and necessary treatment. For appropriate self-management, we suggested classification of the patient’s type by referring to the scales as follows: tension, anxiety-dominant, anger-dominant, depression-dominant, and somatization.
The manual for disaster medical support using Korean medicine for disaster survivors is already developed and published for disaster survivors35). The Manual for Disaster survivors gives understanding of PTSD and suggest various psychological treatment methods such as Stabilization Programs, Emotional Freedom Techniques. However, there are more psychological symptoms caused by COVID-19 than PTSD, and most general Korean Medicine doctors are not familiar with those psychological treatment methods. Most of psychological symptoms caused by COVID-19 are not serious as disaster survivors’ PTSD symptoms and most of patients have power and resilience to overcome such obstacles. So intensive psychotherapy suggested by Manual for Disaster survivors might not be effective if the techniques conducted by unprepared therapists with mild psychological symptoms under the circumstances of COVID-19. Rather self-management techniques such as meditation is more useful for patients with mild symptoms which most patients are126) and meditations are more familiar and can be easily reached and practiced by patients and doctors by Internet or YouTube. Therefor doctors on the front lines facing the problem, it is important to identify at-risk patients and diagnose high-risk groups. Quickly identify at-risk patients and high-risk groups, and have experts apply the developed disaster manual or other manual for mental disorders. For those who are not serious psychological support, conventional Korean Medicine intervention and meditation techniques are sufficient126).
The strengths of this study is that the manual provides a clinical pathway and this manual is developed with a focus on primary medical care where patients come with mental pain caused by the COVID-19 outbreak rather than disaster sites to increase the usability of the manual. In addition, we tried to consider situation of primary practice and experts’ experiences and through literature search, additional considerations in the clinical field were reinforced through the research of other clinical experts. Finally, this manual is developed for a specific disaster situation ‘COVID-19’. Disasters such as epidemics of infectious diseases have different characteristics from general disasters such as natural disasters, war, terror, and accidents. Epidemic disasters are continuously increasing, and this manual contains the concept of epidemic disasters and can be referred to disasters caused by other epidemic diseases that will occur in the future.
However, this study had several limitations. First, this manual was developed by a small research team at the KMMH center based on the narrative review. This is not developed by evidence-based methodologies but by informal consensus development methods. More rigorous methodological reinforcement and a formal consensus process (e.g., focused group interview, Delphi methods, or opening of public hearing) is required. Second, this manual has not been empirically tested. We need to collect and report a case or case series compliant with this manual and conduct clinical research to investigate the contents of the manual. Lastly, we did not include much information about herbal medicine and acupuncture, and focused on self-management in the manual. As mentioned above, we emphasize psychological education, mind-body intervention, and psychotherapy over herbal medicine and acupuncture for a stressful population during the COVID-19 pandemic.


This manual suggests several clinical implications. Firstly, psychological complaints of patients during the pandemic need to be preferentially considered as natural responses or phenomena rather than major psychiatric disorders. Thus, we suggested risk screening for all patients in order to manage the patients regarding their severity. If necessary, practitioners have to treat the patients as mental disorders or referral the patients to higher-level medical institutions. For this, this manual suggests essential scales which can be easily used in primary clinics. Secondly, doctors of Korean medicine should systematically classify patients who visit primary care institutions based on the patterns of the symptoms as follows: tension, anxiety-dominant, anger-dominant, depression-dominant, and somatization. Self-management also had better to be delivered individually according to patients’ status. This manual would help doctors of Korean medicine decide the type of self-management modalities for the patients. Finally, in doing so, we expect the use of this manual in Korean medicine as well as in other primary care institutions, public health centers, and local health centers.

Supplementary Material

Supplementary Table 1.

Search terms




Financial support

This work was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HF20C0079).

Data availability

The original contributions presented in the study are included in the article/supplementary materials, and further inquiries can be directed to the corresponding author.

Ethical statement

No ethics approval was needed.

Fig. 1
Analysis flowchart
Fig. 2
Overview of Development of the Manual.
Fig. 3
Treatment plan flowchart for psychiatric symptoms during the COVID-19 pandemic
CGI-I: Clinical global impression-improvement; GAD-7: Generalized anxiety disorder-7; MBI: Mibyeong index; NRS: Numerical rating scale; PC-PTSD: Primary care posttraumatic stress disorder screen; PHQ-9: Patient health questionnaire-9; PMR: Progressive muscle relaxation
Table 1
Causes of psychiatric problems during the COVID-19 pandemic
Main Theme Subtheme
Personal factors Age, sex, marital status, educational level, housing, income, and employment status
Underlying disease or history of mental illness (e.g., cognitive disorder, emotional or behavioral disorder, or other mental disorders)
Coping mechanisms
Personal protective measures
Perceived chance of survival
Weak solidarity with others
Factors directly correlated to the virus Direct or close contact with the infected
Infected family, relatives, friends
Social factors COVID-19-related news in the mainstream media or on social media
National policy
Isolation (social distancing, quarantine)
Stigma, psychological support
Medical system

COVID-19: coronavirus disease

Table 2
Psychiatric symptoms and disorders during the COVID-19 pandemic
Main Theme Subtheme(s)
Spectrum of psychiatric symptoms and disorders A patient predisposed to a major mental disorder: a new episode of mental breakdown
A patient with a preexisting disorder: rapid exacerbation; or occurrence of disorders related to trauma or stress factors (acute stress disorder, posttraumatic stress disorder, adjustment disorder)
Psychiatric symptoms associated with stress responses that do not meet diagnostic criteria for mental disorders
Psychiatric disorders closely related to COVID-19 infection or the COVID-19 pandemic
Emotional disturbance Anxiety and fear: anxiety disorder, panic disorder, posttraumatic stress disorder
Anger: hypersensitivity, impulsiveness, addiction, intemperance
Depression: guilt, boredom, pessimism, low self-esteem, and suicidal ideation or behavior
Somatization Sleep disturbance, hyper-arousal, fatigue, exhaustion
Reactions to external stimuli Domestic violence, discrimination, and xenophobia

COVID-19: coronavirus disease

Table 3
Therapeutic approaches to mental health during the COVID-19 pandemic
Main Theme Subtheme(s)
Personal care Healthy living, regular exercise, balanced nutrition, good sleep, outdoor and physical activity, routinized daily life, improved resilience, strong bonds with others, solidarity with others, individual religious practice, psychotherapy such as mindfulness, community-based art therapy programs, and cultural interventions
Remote medical treatment Remote counseling, group-based cognitive behavioral therapy, psychological emergency care, and bibliotherapy
Medication treatment Psychotropic drugs for COVID-19 patients and calcium channel blockers for dementia patients.
Herbal medicine treatment Posttraumatic stress disorder: Lily Bulb and Rehmannia Decoction and Guilu Erxian Decoction
Anxiety: Suanzaoren Decoction, Huanglian Ejiao Decoction, and Zhizi Chi Decoction
Depression: Lily Bulb and Rehmannia Decoction, Lily Bulb and Anemarrhenae Decoction, and Ganmai Dazao Decoction

COVID-19: coronavirus disease

Table 4
Key recommendations: Evaluation of mental health during the COVID-19 pandemic
Purposes Evaluation scales
Initial assessment Numerical Rating Scale

Suicidal risk screening P4-Suicide-Risk-Screener

Mental health screening
 Posttraumatic stress disorder (PTSD) Primary Care PTSD Screen (PC-PTSD)
 Depressive disorders Patient Health Questionnaire-9 (PHQ-9)
 Generalized anxiety disorder Generalized Anxiety Disorder-7 (GAD-7)
 Hwabyung (Anger syndrome) Hwabyung Scale

Type assessment Mibyeong Index

Evaluation of treatment effects
 General Mibyeong Index
Clinical Global Impression-Improvement (CGI-I)

 Tension Stress Response Inventory (SRI)

 Anxiety Impact of Event Scale-Revised (IES-R)
State-Trait Anxiety Inventory (STAI)

 Anger Hwabyung Scale
State-Trait Anger Expression Inventory (STAXI)

 Depression Beck Depression Inventory-II (BDI-II)

Somatization Patient Health Questionnaire-15 (PHQ-15)

COVID-19: coronavirus disease; PTSD: posttraumatic stress disorder

Table 5
Key recommendations: Pattern types of moderate to high risk patients
Pattern type Mibyeong index profile Chief complaints
Tension All scores within each domain are high Ambiguous or sensitive physical and emotional symptoms
Anxiety-dominant A score within the anxiety domain is dominantly higher than other domains Palpitation, chest discomfort
Anger-dominant A score within the anger domain is dominantly higher than other domains Irritability, hypersensitivity, addiction, chest pain, headache, fever
Depression-dominant A score within the depression domain is dominantly higher than other domains Decreased interest, loss of appetite, lethargy
Somatization Scores within physical domains (i.e., fatigue, pain, insomnia, or dyspepsia) are generally higher than scores within emotional domains (i.e., anger, depression, or anxiety) Sleep disturbance, fatigue, pain
Table 6
Key recommendations: Self-management according to the types
Patient classification Self-management
Low risk
  • Psychoeducation

  • Deep breathing

  • Breathing meditation

  • Walking meditation

Moderate to high risk
  • Progressive muscle relaxation

  • Autogenic training

  • Mindfulness sitting meditation

  • Breath-counting meditation

  • Mindfulness sitting meditation

  • Loving-kindness meditation

  • Mindfulness eating meditation

  • Body scan meditation

  • Brief Qigong-based stress reduction program


1. National Center for Disaster and Trauma. 2020. Psychological support guideline for novel corona virus. Ministry of Health and Welfare.

2. World Health Organization. 2021. COVID-19 weekly epidemiological update, edition 68. 30. November. 2021. https://apps.who.int/iris/handle/10665/350006

3. Han RH, Schmidt MN, Waits WM, Bell AK, Miller TL. 2020; Planning for mental health needs during COVID-19. Curr Psychiatry Rep. 22:12. 1–10. https://doi.org/10.1007/s11920-020-01189-6

4. Robillard R, Saad M, Edwards J, Solomonova E, Pennestri MH, Daros A, Veissière SPL, Quilty L, Dion K, Nixon A, Phillips J, Bhatla R, Spilg E, Godbout R, Yazji B, Rushton C, Gifford WA, Gautam M, Boafo A, Swartz R, Kendzerska T. 2020; Social, financial and psychological stress during an emerging pandemic: observations from a population survey in the acute phase of COVID-19. BMJ open. 10:12. e043805 http://dx.doi.org/10.1136/bmjopen-2020-043805
crossref pmid pmc

5. Galbraith N, Boyda D, McFeeters D, Hassan T. 2021; The mental health of doctors during the COVID-19 pandemic. BJPsych bulletin. 45:2. 93–97. https://doi.org/10.1192/bjb.2020.44
crossref pmid pmc

6. Kathirvel N. 2020; Post COVID-19 pandemic mental health challenges. Asian J Psychiatr. 53:102430 https://doi.org/10.1016/j.ajp.2020.102430
crossref pmid pmc

7. Wang J, Mann F, Lloyd-Evans B, Ma R, Johnson S. 2018; Associations between loneliness and perceived social support and outcomes of mental health problems: a systematic review. BMC psychiatry. 18:1. 1–16. https://doi.org/10.1186/s12888-018-1736-5
pmid pmc

8. Ernst M, Niederer D, Werner AM, Czaja SJ, Mikton C, Ong AD, Rosen T, Brähler E, Beutel ME. 2022; Loneliness before and during the COVID-19 pandemic: A systematic review with meta-analysis. American Psychologist. https://doi.org/10.1037/amp0001005
crossref pmid

9. Molteni F, Ladini R, Biolcati F, Chiesi AM, Dotti Sani GM, Guglielmi S, Maraffi M, Pedrazzani A, Segatti P, Vezzoni C. 2021; Searching for comfort in religion: insecurity and religious behaviour during the COVID-19 pandemic in Italy. European Societies. 23:sup1. S704–S720. https://doi.org/10.1080/14616696.2020.1836383

10. Saltzman LY, Hansel TC, Bordnick PS. 2020; Loneliness, isolation, and social support factors in post-COVID-19 mental health. Psychol Trauma. 12:S1. S55–S57. https://doi.org/10.1037/tra0000703

11. Division of Mental Health Management, Ministry of Health and Welfare. 2021. Q2 2021 “COVID19 National Mental Health Survey” Results Report. Ministry of Health and Welfare.

12. National Medical Center. 2021. 2021 “COVID-19 Public Awareness Survey” Results Report. National Medical Center.

13. Andrade G, Simões do Couto F, Câmara-Pestana L. 2020; Recommendations about the use of psychotropic medications during the COVID-19 pandemic. Acta Med Port. 33:10. 693–702. https://doi.org/10.20344/amp.13976

14. Danta CC. 2020; Calcium channel blockers: a possible potential therapeutic strategy for the treatment of Alzheimer’s dementia patients with SARS-CoV-2 infection. ACS Chem Neurosci. 11:15. 2145–2148. https://doi.org/10.1021/acschemneuro.0c00391
crossref pmid

15. Sabe M, Dorsaz O, Huguelet P, Kaiser S. 2021; Toxicity of psychotropic drugs in patients with COVID-19: a systematic review. Gen Hosp Psychiatry. 70:1–9. https://doi.org/10.1016/j.genhosppsych.2021.02.006
crossref pmid pmc

16. Bilbul M, Paparone P, Kim AM, Mutalik S, Ernst CL. 2020; Psychopharmacology of COVID-19. Psychosomatics. 61:5. 411–427. https://doi.org/10.1016/j.psym.2020.05.006
crossref pmid pmc

17. Rogers JP, Chesney E, Oliver D, Pollak TA, McGuire P, Fusar-Poli P, Zandi MS, Lewis G, David AS. 2020; Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry. 7:7. 611–627. https://doi.org/10.1016/S2215-0366(20)30203-0
crossref pmid pmc

18. Werner EA, Aloisio CE, Butler AD, D’Antonio KM, Kenny JM, Mitchell A, Ona S, Monk C. 2020; Addressing mental health in patients and providers during the COVID-19 pandemic. Semin Perinatol. 44:7. 151279 https://doi.org/10.1016/j.semperi.2020.151279
crossref pmid pmc

19. Jang S, Kim D, Yi E, Choi G, Song M, Lee E-K. 2021; Telemedicine and the use of Korean medicine for patients with COVID-19 in South Korea: observational study. JMIR Public Health Surveill. 7:1. e20236 https://doi.org/10.2196/20236

20. Kim D-S, Chu H, Min BK, Moon Y, Park S, Kim K, Park S-H, Kim Y-D, Song M, Choi G-H, Lee E. 2020; Telemedicine center of Korean medicine for treating patients with COVID-19: a retrospective analysis. Integr Med Res. 9:3. 100492 https://doi.org/10.1016/j.imr.2020.100492
crossref pmid pmc

21. Kwon C-Y, Kwak H-Y, Kim JW. 2020; Using mind–body modalities via telemedicine during the COVID-19 crisis: cases in the Republic of Korea. Int J Environ Res Public Health. 17:12. 4477 https://doi.org/10.3390/ijerph17124477
crossref pmid pmc

22. Jain FA, Walsh RN, Eisendrath SJ, Christensen S, Cahn BR. 2015; Critical analysis of the efficacy of meditation therapies for acute and subacute phase treatment of depressive disorders: a systematic review. Psychosomatics. 56:2. 140–152. https://doi.org/10.1016/j.psym.2014.10.007
crossref pmid pmc

23. McCartney M, Nevitt S, Lloyd A, Hill R, White R, Duarte R. 2021; Mindfulness-based cognitive therapy for prevention and time to depressive relapse: Systematic review and network meta-analysis. Acta Psychiatrica Scandinavica. 143:1. 6–21. https://doi.org/10.1111/acps.13242

24. V⊘llestad J, Nielsen MB, Nielsen GH. 2012; Mindfulness-and acceptance-based interventions for anxiety disorders: A systematic review and meta-analysis. British journal of clinical psychology. 51:3. 239–260. https://doi.org/10.1111/j.2044-8260.2011.02024.x
crossref pmid

25. Zhou X, Guo J, Lu G, Chen C, Xie Z, Liu J, Zhang C. 2020; Effects of mindfulness-based stress reduction on anxiety symptoms in young people: A systematic review and meta-analysis. Psychiatry Research. 289:113002 https://doi.org/10.1016/j.psychres.2020.113002
crossref pmid

26. Hilton L, Maher AR, Colaiaco B, Apaydin E, Sorbero ME, Booth M, Marika S, Roberta M, Hempel S. 2017; Meditation for posttraumatic stress: Systematic review and meta-analysis. Psychological Trauma: Theory, Research, Practice, and Policy. 9:4. 453 https://doi.org/10.1037/tra0000180
crossref pmid

27. Goyal M, Singh S, Sibinga EMS, Gould NF, Rowland-Seymour A, Sharma R, Berger Z, Sleicher D, Maron DD, Shihab HM, Ranasinghe PD, Linn S, Saha S, Bass EB, Haythornthwaite JA. 2014; Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA internal medicine. 174:3. 357–368. 10.1001/jamainternmed.2013.13018
crossref pmid pmc

28. Sharma M, Rush SE. 2014; Mindfulness-based stress reduction as a stress management intervention for healthy individuals: a systematic review. Journal of evidence-based complementary & alternative medicine. 19:4. 271–286. https://doi.org/10.1177/2156587214543143

29. Pascoe MC, Thompson DR, Jenkins ZM, Ski CF. 2017; Mindfulness mediates the physiological markers of stress: Systematic review and meta-analysis. Journal of psychiatric research. 95:156–178. https://doi.org/10.1016/j.jpsychires.2017.08.004
crossref pmid

30. Rusch HL, Rosario M, Levison LM, Olivera A, Livingston WS, Wu T, Gill JM. 2019; The effect of mindfulness meditation on sleep quality: a systematic review and meta-analysis of randomized controlled trials. Annals of the New York Academy of Sciences. 1445:1. 5–16. https://doi.org/10.1111/nyas.13996

31. EBM-based Guidelines Development Committee for Korean Medicine Clinical Practice Guideline for Depression (Korea Institute of Oriental Medicine and Society of Korean Medicine Neuropsychiatry). 2016. Korean Medicine Clinical Practice Guideline for Depression. Deajeon, Korea: Elsevier Korea.

32. The Society of Korean Medicine Neuropsychiatry. 2021. Clinical practice guideline of Korean medicine for anxiety disorders. Guideline Center for Korean Medicine (G-KoM), National Development Institute of Korean Medicine.

33. The Society of Korean Medicine Neuropsychiatry. 2021. Clinical practice guideline of Korean medicine for insomnia disorder. Guideline Center for Korean Medicine (G-KoM), National Development Institute of Korean Medicine.

34. The Society of Korean Medicine Neuropsychiatry. Clinical practice guideline of Korean medicine for Hwabyung. 2021: Guideline Center for Korean Medicine (G-KoM), National Development Institute of Korean Medicine.

35. Kwon CY, Seo J, Kim SH. 2022; Development of a Manual for Disaster Medical Support Using Korean Medicine for Disaster Survivors. Journal of integrative and complementary medicine. https://doi.org/10.1089/jicm.2022.0561
crossref pmid

36. Behan C. 2020; The benefits of meditation and mindfulness practices during times of crisis such as COVID-19. Irish journal of psychological medicine. 37:4. 256–258. https://doi.org/10.1017/ipm.2020.38
crossref pmid pmc

37. Jiménez Ó, Sánchez-Sánchez LC, García-Montes JM. 2020; Psychological impact of COVID-19 confinement and its relationship with meditation. International Journal of Environmental Research and Public Health. 17:18. 6642 https://doi.org/10.3390/ijerph17186642
crossref pmid pmc

38. Rasania SK. 2021; A cross--sectional study of mental wellbeing with practice of yoga and meditation during COVID-19 pandemic. Journal of Family Medicine and Primary Care. 10:4. 157610.4103/jfmpc.jfmpc_2367_20
crossref pmid pmc

39. Hossain MM, Tasnim S, Sultana A, Faizah F, Mazumder H, Zou L, McKyer ELJ, Ahmed HU, Ma P. 2020; Epidemiology of mental health problems in COVID-19: a review. F1000Res. 9:636 https://doi.org/10.12688/f1000research.24457.1
pmid pmc

40. Chevance A, Gourion D, Hoertel N, Llorca PM, Thomas P, Bocher R, Moro MR, Laprévote V, Benyamina A, Fossati P, Masson M, Leaune E, Leboyer M, Gaillard R. 2020; Ensuring mental health care during the SARS-CoV-2 epidemic in France: a narrative review. Encephale. 46:3. 193–201. https://doi.org/10.1016/j.encep.2020.04.005
crossref pmid pmc

41. Silva AFD, Estrela FM, Soares CFS, Magalhães JRFD, Lima NS, Morais AC, Gomes NP, Lima VLDA. 2020; Marital violence precipitating/intensifying elements during the Covid-19 pandemic. Cien Saude Colet. 25:9. 3475–3480. https://doi.org/10.1590/1413-81232020259.16132020

42. Gilan D, Röthke N, Blessin M, Kunzler A, Stoffers-Winterling J, Müssig M, Yuen KSL, Tüscher O, Thrul J, Kreuter F, Sprengholz P, Betsch C, Stieglitz RD, Lieb K. 2020; Psychomorbidity, resilience, and exacerbating and protective factors during the SARS-CoV-2 pandemic. Dtsch Arztebl Int. 117:38. 625–630. https://doi.org/10.3238/arztebl.2020.0625
crossref pmid pmc

43. Kunzler AM, Röthke N, Günthner L, Stoffers-Winterling J, Tüscher O, Coenen M, Rehfuess E, Schwarzer G, Binder H, Schmucker C, Meerpohl JJ, Lieb K. 2021; Mental burden and its risk and protective factors during the early phase of the SARS-CoV-2 pandemic: systematic review and meta-analyses. Global Health. 17:1. 34 https://doi.org/10.1186/s12992-021-00670-y
pmid pmc

44. Taylor S. 2021; COVID stress syndrome: clinical and nosological considerations. Curr Psychiatry Rep. 23:4. 19 https://doi.org/10.1007/s11920-021-01226-y
pmid pmc

45. Xiong J, Lipsitz O, Nasri F, Lui LMW, Gill H, Phan L, Chen-Li D, Iacobucci M, Ho R, Majeed A, McIntyre RS. 2020; Impact of COVID-19 pandemic on mental health in the general population: a systematic review. J Affect Disord. 277:55–64. https://doi.org/10.1016/j.jad.2020.08.001
crossref pmid pmc

46. Heiat M, Heiat F, Halaji M, Ranjbar R, Tavangar Marvasti Z, Yaali-Jahromi E, Azizi MM, Morteza Hosseini S, Badri T. 2021; Phobia and fear of COVID-19: origins, complications and management, a narrative review. Ann Ig. 33:4. 360–370. https://doi.org/10.7416/ai.2021.2446

47. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, Rubin GJ. 2020; The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 395:10227. 912–920. https://doi.org/10.1016/S0140-6736(20)30460-8
crossref pmid pmc

48. Chaimowitz GA, Upfold C, Géa LP, Qureshi A, Moulden HM, Mamak M, Bradford JMW. 2021; Stigmatization of psychiatric and justice-involved populations during the COVID-19 pandemic. Prog Neuropsychopharmacol Biol Psychiatry. 106:110150 https://doi.org/10.1016/j.pnpbp.2020.110150
crossref pmid pmc

49. de Figueiredo CS, Sandre PC, Portugal LCL, Mázala-de-Oliveira T, da Silva Chagas L, Raony Í, Ferreira ES, Giestal-de-Araujo E, Dos Santos AA, Bomfim PO. 2021; COVID-19 pandemic impact on children and adolescents’ mental health: biological, environmental, and social factors. Prog Neuropsychopharmacol Biol Psychiatry. 106:110171 https://doi.org/10.1016/j.pnpbp.2020.110171
crossref pmid pmc

50. Kotlar B, Gerson E, Petrillo S, Langer A, Tiemeier H. 2021; The impact of the COVID-19 pandemic on maternal and perinatal health: a scoping review. Reprod Health. 18:1. 10 https://doi.org/10.1186/s12978-021-01070-6
pmid pmc

51. Grolli RE, Mingoti MED, Bertollo AG, Luzardo AR, Quevedo J, Réus GZ, Ignácio ZM. 2021; Impact of COVID-19 in the mental health in elderly: psychological and biological updates. Mol Neurobiol. 58:5. 1905–1916. https://doi.org/10.1007/s12035-020-02249-x
pmid pmc

52. Mosolov SN. 2020; Problems of mental health in the situation of COVID-19 pandemic. Zh Nevrol Psikhiatr Im S S Korsakova. 120:5. 7–15. https://doi.org/10.17116/jnevro20201200517
crossref pmid

53. Vanessa CF, Iarocci G. 2020; Child and family outcomes following pandemics: a systematic review and recommendations on COVID-19 policies. J Pediatr Psychol. 45:10. 1124–1143. https://doi.org/10.1093/jpepsy/jsaa092

54. Cabrera MA, Karamsetty L, Simpson SA. 2020; Coronavirus and its implications for psychiatry: a rapid review of the early literature. Psychosomatics. 61:6. 607–615. https://doi.org/10.1016/j.psym.2020.05.018
crossref pmid pmc

55. Mazhar K, Hussain S, Ullah R, Raza H, Aamir A, Asif A, Memon FS, Haider J, Anas M. 2020; Mental health crisis in pregnant women during current COVID-19 pandemic. Psychiatr Danub. 32:3–4. 598–599.

56. Cosco TD, Fortuna K, Wister A, Riadi I, Wagner K, Sixsmith A. 2021; COVID-19, social isolation, and mental health among older adults: a digital catch-22. J Med Internet Res. 23:5. e21864 https://doi.org/10.2196/21864
crossref pmid pmc

57. da Silva FCT, Neto MLR. 2021; Psychiatric symptomatology associated with depression, anxiety, distress, and insomnia in health professionals working in patients affected by COVID-19: a systematic review with meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 104:110057 https://doi.org/10.1016/j.pnpbp.2020.110057
crossref pmid pmc

58. da Silva FCT, Neto MLR. 2021; Psychological effects caused by the COVID-19 pandemic in health professionals: a systematic review with meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 104:110062 https://doi.org/10.1016/j.pnpbp.2020.110062
crossref pmid pmc

59. Varghese A, George G, Kondaguli SV, Naser AY, Khakha DC, Chatterji R. 2021; Decline in the mental health of nurses across the globe during COVID-19: a systematic review and meta-analysis. J Glob Health. 11:05009 https://doi.org/10.7189/jogh.11.05009
crossref pmid pmc

60. d’Ettorre G, Ceccarelli G, Santinelli L, Vassalini P, Innocenti GP, Alessandri F, Koukopoulos AE, Russo A, d’Ettorre G, Tarsitani L. 2021; Post-traumatic stress symptoms in healthcare workers dealing with the COVID-19 pandemic: a systematic review. Int J Environ Res Public Health. 18:2. 601 https://doi.org/10.3390/ijerph18020601
crossref pmid pmc

61. Júnior JG, Moreira MM, Pinheiro WR, de Amorim LM, Lima CKT, da Silva CGL, Neto MLR. 2020; The mental health of those whose rights have been taken away: an essay on the mental health of indigenous peoples in the face of the 2019 coronavirus (2019-nCoV) outbreak. Psychiatry Res. 289:113094 https://doi.org/10.1016/j.psychres.2020.113094
crossref pmid pmc

62. Furlong Y, Finnie T. 2020; Culture counts: the diverse effects of culture and society on mental health amidst COVID-19 outbreak in Australia. Ir J Psychol Med. 37:3. 237–242. https://doi.org/10.1017/ipm.2020.37
crossref pmid pmc

63. Rothman S, Gunturu S, Korenis P. The mental health impact of the COVID-19 epidemic on immigrants and racial and ethnic minorities. QJM. 113:11. 779–782. https://doi.org/10.1093/qjmed/hcaa203

64. Mukherjee S. 2020; Disparities, desperation, and divisiveness: coping with COVID-19 in India. Psychol Trauma. 12:6. 582–584. https://doi.org/10.1037/tra0000682
crossref pmid

65. Almeida M, Shrestha AD, Stojanac D, Miller LJ. 2020; The impact of the COVID-19 pandemic on women’s mental health. Arch Womens Ment Health. 23:6. 741–748. https://doi.org/10.1007/s00737-020-01092-2
pmid pmc

66. Esterwood E, Saeed SA. 2020; Past epidemics, natural disasters, COVID19, and mental health: learning from history as we deal with the present and prepare for the future. Psychiatr Q. 91:4. 1121–1133. https://doi.org/10.1007/s11126-020-09808-4
pmid pmc

67. Mengin A, Allé MC, Rolling J, Ligier F, Schroder C, Lalanne L, Berna F, Jardri R, Vaiva G, Geoffroy PA, Brunault P, Thibaut F, Chevance A, Giersch A. 2020; Psychopathological consequences of confinement. Encephale. 46:3S. S43–S52. https://doi.org/10.1016/j.encep.2020.04.007
pmid pmc

68. Chew QH, Wei KC, Vasoo S, Chua HC, Sim K. 2020; Narrative synthesis of psychological and coping responses towards emerging infectious disease outbreaks in the general population: practical considerations for the COVID-19 pandemic. Singapore Med J. 61:7. 350–356. https://doi.org/10.11622/smedj.2020046
crossref pmid pmc

69. Henssler J, Stock F, van Bohemen J, Walter H, Heinz A, Brandt L. 2021; Mental health effects of infection containment strategies: quarantine and isolation-a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci. 271:2. 223–234. https://doi.org/10.1007/s00406-020-01196-x

70. Blum K, Cadet JL, Baron D, Badgaiyan RD, Brewer R, Modestino EJ, Gold MS. 2020; Putative COVID-19 induction of reward deficiency syndrome (RDS) and associated behavioral addictions with potential concomitant dopamine depletion: is COVID-19 social distancing a double edged sword? Subst Use Misuse. 55:14. 2438–2442. https://doi.org/10.1080/10826084.2020.1817086
crossref pmid

71. Sher L. 2020; The impact of the COVID-19 pandemic on suicide rates. QJM. 113:10. 707–712. https://doi.org/10.1093/qjmed/hcaa202

72. Fatke B, Hölzle P, Frank A, Förstl H. 2020; COVID-19 crisis: early observations on a pandemic’s psychiatric problems. Dtsch Med Wochenschr. 145:10. 675–681. https://doi.org/10.1055/a-1147-2889
crossref pmid

73. Anjum S, Ullah R, Rana MS, Khan HA, Memon FS, Ahmed Y, Jabeen S, Faryal R. 2020; COVID-19 pandemic: a serious threat for public mental health globally. Psychiatr Danub. 32:2. 245–250. https://doi.org/10.24869/psyd.2020.245
crossref pmid

74. Mallet J, Dubertret C, Le Strat Y. 2021; Addictions in the COVID-19 era: current evidence, future perspectives a comprehensive review. Prog Neuropsychopharmacol Biol Psychiatry. 106:110070 https://doi.org/10.1016/j.pnpbp.2020.110070
crossref pmid pmc

75. Bailey KL, Samuelson DR, Wyatt TA. 2021; Alcohol use disorder: a pre-existing condition for COVID-19? Alcohol. 90:11–17. https://doi.org/10.1016/j.alcohol.2020.10.003
crossref pmid pmc

76. He Y, Yu R, Ren J. 2021; The correlation between psychiatric disorders and COVID-19: a narrative review. Psychiatr Danub. 33:1. 76–85. https://doi.org/10.24869/psyd.2021.76
crossref pmid

77. Preti E, Di Pierro R, Fanti E, Madeddu F, Calati R. 2020; Personality disorders in time of pandemic. Curr Psychiatry Rep. 22:12. 80 https://doi.org/10.1007/s11920-020-01204-w
pmid pmc

78. Sulaimani MF, Bagadood NH. Implication of coronavirus pandemic on obsessive-compulsive-disorder symptoms. Rev Environ Health. 36:1. 1–8. https://doi.org/10.1515/reveh-2020-0054
crossref pmid

79. Salehi M, Amanat M, Mohammadi M, Salmanian M, Rezaei N, Saghazadeh A, Garakani A. 2021; The prevalence of post-traumatic stress disorder related symptoms in coronavirus outbreaks: a systematic-review and meta-analysis. J Affect Disord. 282:527–538. https://doi.org/10.1016/j.jad.2020.12.188
crossref pmid pmc

80. Cooke JE, Eirich R, Racine N, Madigan S. 2020; Prevalence of posttraumatic and general psychological stress during COVID-19: a rapid review and meta-analysis. Psychiatry Res. 292:113347 https://doi.org/10.1016/j.psychres.2020.113347
crossref pmid pmc

81. da Silva ML, Rocha RSB, Buheji M, Jahrami H, Cunha KDC. 2021; A systematic review of the prevalence of anxiety symptoms during coronavirus epidemics. J Health Psychol. 26:1. 115–125. https://doi.org/10.1177/1359105320951620

82. Numbers K, Brodaty H. 2021; The effects of the COVID-19 pandemic on people with dementia. Nat Rev Neurol. 17:2. 69–70. https://doi.org/10.1038/s41582-020-00450-z
pmid pmc

83. Iodice F, Cassano V, Rossini PM. 2021; Direct and indirect neurological, cognitive, and behavioral effects of COVID-19 on the healthy elderly, mild-cognitive-impairment, and Alzheimer’s disease populations. Neurol Sci. 42:2. 455–465. https://doi.org/10.1007/s10072-020-04902-8
pmid pmc

84. Javelot H, Weiner L. 2021; Panic and pandemic: narrative review of the literature on the links and risks of panic disorder as a consequence of the SARS-CoV-2 pandemic. Encephale. 47:1. 38–42. https://doi.org/10.1016/j.encep.2020.08.001
crossref pmid pmc

85. Hernández-Gómez A, Andrade-González N, Lahera G, Vieta E. 2021; Recommendations for the care of patients with bipolar disorder during the COVID-19 pandemic. J Affect Disord. 279:117–121. https://doi.org/10.1016/j.jad.2020.09.105
crossref pmid pmc

86. Costanza A, Di Marco S, Burroni M, Corasaniti F, Santinon P, Prelati M, Chytas V, Cedraschi C, Ambrosetti J. 2020; Meaning in life and demoralization: a mental-health reading perspective of suicidality in the time of COVID-19. Acta Biomed. 91:4. e2020163 https://doi.org/10.23750/abm.v91i4.10515
pmid pmc

87. Conejero I, Berrouiguet S, Ducasse D, Leboyer M, Jardon V, Olié E, Courtet P. 2020; Suicidal behavior in light of COVID-19 outbreak: clinical challenges and treatment perspectives. Encephale. 46:3S. S66–S72. https://doi.org/10.1016/j.encep.2020.05.001
pmid pmc

88. Walsh O, McNicholas F. 2020; Assessment and management of anorexia nervosa during COVID-19. Ir J Psychol Med. 37:3. 187–191. https://doi.org/10.1017/ipm.2020.60
crossref pmid pmc

89. Jahrami H, BaHammam AS, Bragazzi NL, Saif Z, Faris M, Vitiello MV. 2021; Sleep problems during the COVID-19 pandemic by population: a systematic review and meta-analysis. J Clin Sleep Med. 17:2. 299–313. https://doi.org/10.5664/jcsm.8930
crossref pmid pmc

90. Datta K, Tripathi M. 2021; Sleep and Covid-19. Neurol India. 69:1. 26–31. https://doi.org/10.4103/0028-3886.310073
crossref pmid

91. Souza LFF, Paineiras-Domingos LL, Melo-Oliveira MES, Pessanha-Freitas J, Moreira-Marconi E, Lacerda ACR, Mendonça VA, Sá-Caputo DDC, Bernardo-Filho M. 2021; The impact of COVID-19 pandemic in the quality of sleep by Pittsburgh Sleep Quality Index: a systematic review. Cien Saude Colet. 26:4. 1457–1466. https://doi.org/10.1590/1413-81232021264.45952020
crossref pmid

92. Kim SW, Su KP. 2020; Using psychoneuroimmunity against COVID-19. Brain Behav Immun. 87:4–5. https://doi.org/10.1016/j.bbi.2020.03.025
crossref pmid pmc

93. Puyat JH, Ahmad H, Avina-Galindo AM, Kazanjian A, Gupta A, Ellis U, Ashe MC, Vila-Rodriguez F, Halli P, Salmon A, Vigo D, Almeida A, De Bono CE. 2020; A rapid review of home-based activities that can promote mental wellness during the COVID-19 pandemic. PLoS One. 15:12. e0243125 https://doi.org/10.1371/journal.pone.0243125
crossref pmid pmc

94. Hou WK, Lai FT, Ben-Ezra M, Goodwin R. 2020; Regularizing daily routines for mental health during and after the COVID-19 pandemic. J Glob Health. 10:2. 020315 https://doi.org/10.7189/jogh.10.020315
crossref pmid pmc

95. Jakovljevic M, Jakovljevic I, Bjedov S, Mustac F. 2020; Psychiatry for better world: COVID-19 and blame games people play from public and global mental health perspective. Psychiatr Danub. 32:2. 221–228. https://doi.org/10.24869/psyd.2020.221

96. Blanc J, Briggs AQ, Seixas AA, Reid M, Jean-Louis G, Pandi-Perumal SR. 2021; Addressing psychological resilience during the coronavirus disease 2019 pandemic: a rapid review. Curr Opin Psychiatry. 34:1. 29–35. https://doi.org/10.1097/YCO.0000000000000665
crossref pmid pmc

97. Williams CYK, Townson AT, Kapur M, Ferreira AF, Nunn R, Galante J, Phillips V, Gentry S, Usher-Smith JA. 2021; Interventions to reduce social isolation and loneliness during COVID-19 physical distancing measures: a rapid systematic review. PLoS One. 16:2. e0247139 https://doi.org/10.1371/journal.pone.0247139
crossref pmid pmc

98. Prisco V, Prisco L, Donnarumma B. 2020; Telepsychiatry in adults and adolescents: a useful tool against CoViD-19. Recenti Prog Med. 111:7. 411–414. https://doi.org/10.1701/3407.33923

99. Di Carlo F, Sociali A, Picutti E, Pettorruso M, Vellante F, Verrastro V, Martinotti G, di Giannantonio M. 2021; Telepsychiatry and other cutting-edge technologies in COVID-19 pandemic: bridging the distance in mental health assistance. Int J Clin Pract. 75:1. 10.1111/ijcp.13716 https://doi.org/10.1111/ijcp.13716

100. Yue JL, Yan W, Sun YK, Yuan K, Su SZ, Han Y, Ravindran AV, Kosten T, Everall I, Davey CG, Bullmore E, Kawakami N, Barbui C, Thornicroft G, Lund C, Lin X, Liu L, Shi L, Shi J, Ran MS, Bao YP, Lu L. 2020; Mental health services for infectious disease outbreaks including COVID-19: a rapid systematic review. Psychol Med. 50:15. 2498–2513. https://doi.org/10.1017/S0033291720003888
crossref pmid pmc

101. Zhang M, Smith HE. 2020; Digital tools to ameliorate psychological symptoms associated with COVID-19: scoping review. J Med Internet Res. 22:8. e19706 https://doi.org/10.2196/19706
crossref pmid pmc

102. Simpson S, Richardson L, Pietrabissa G, Castelnuovo G, Reid C. 2021; Videotherapy and therapeutic alliance in the age of COVID-19. Clin Psychol Psychother. 28:2. 409–421. https://doi.org/10.1002/cpp.2521

103. Monroy-Fraustro D, Maldonado-Castellanos I, Aboites-Molina M, Rodríguez S, Sueiras P, Altamirano-Bustamante NF, de Hoyos-Bermea A, Altamirano-Bustamante MM. 2021; Bibliotherapy as a non-pharmaceutical intervention to enhance mental health in response to the COVID-19 pandemic: a mixed-methods systematic review and bioethical meta-analysis. Front Public Health. 9:629872 https://doi.org/10.3389/fpubh.2021.629872
crossref pmid pmc

104. Ma K, Wang X, Feng S, Xia X, Zhang H, Rahaman A, Dong Z, Lu Y, Li X, Zhou X, Zhao H, Wang Y, Wang S, Baloch Z. 2020; From the perspective of traditional Chinese medicine: treatment of mental disorders in COVID-19 survivors. Biomed Pharmacother. 132:110810 https://doi.org/10.1016/j.biopha.2020.110810
crossref pmid pmc

105. Shahrajabian MH, Sun W, Soleymani A, Cheng Q. 2021; Traditional herbal medicines to overcome stress, anxiety and improve mental health in outbreaks of human coronaviruses. Phytother Res. 35:3. 1237–1247. https://doi.org/10.1002/ptr.6888

106. Park JE, Kang S-H, Won S-D, Roh D, Kim W-H. 2015; Assessment instruments for disaster behavioral health. Anxiety and Mood. 11:2. 91–105.

107. Cameron RP, Gusman D. 2003; The primary care PTSD screen (PC-PTSD): development and operating characteristics. Primary care psychiatry. 9:1. 9–14.

108. Kroenke K, Spitzer RL, Williams JB. 2001; The PHQ-9: validity of a brief depression severity measure. Journal of general internal medicine. 16:9. 606–613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x
pmid pmc

109. Arroll B, Goodyear-Smith F, Crengle S, Gunn J, Kerse N, Fishman T, Falloon H, Hatcher S. 2010; Validation of PHQ-2 and PHQ-9 to screen for major depression in the primary care population. The annals of family medicine. 8:4. 348–353. https://doi.org/10.1370/afm.1139
crossref pmid pmc

110. Martin A, Rief W, Klaiberg A, Braehler E. 2006; Validity of the brief patient health questionnaire mood scale (PHQ-9) in the general population. General hospital psychiatry. 28:1. 71–77. https://doi.org/10.1016/j.genhosppsych.2005.07.003

111. Park SJ, Choi HR, Choi JH, Kim KW, Hong JP. 2010; Reliability and validity of the Korean version of the Patient Health Questionnaire-9 (PHQ-9). Anxiety and mood. 6:2. 119–124.

112. Spitzer RL, Kroenke K, Williams JB, Löwe B. 2006; A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of internal medicine. 166:10. 1092–1097. 10.1001/archinte.166.10.1092

113. Löwe B, Decker O, Müller S, Brähler E, Schellberg D, Herzog W, Herzberg PY. 2008. Validation and standardization of the Generalized Anxiety Disorder Screener (GAD-7) in the general population. Medical care. 266–274. https://www.jstor.org/stable/40221654

114. Lee SH, Shin C, Kim H, Jeon SW, Yoon HK, Ko YH, Pae CU, Han C. 2022; Validation of the Korean version of the generalized anxiety disorder 7 self-rating scale. Asia-Pacific Psychiatry. 14:1. e12421 https://doi.org/10.1111/appy.12421

115. Kroenke K, Spitzer RL, Williams JB. 2002; The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosomatic medicine. 64:2. 258–266.
crossref pmid

116. van Ravesteijn H, Wittkampf K, Lucassen P, van de Lisdonk E, van den Hoogen H, van Weert H, Huijser J, Schene A, van Weel C, Speckens A. 2009; Detecting somatoform disorders in primary care with the PHQ-15. The Annals of Family Medicine. 7:3. 232–238. https://doi.org/10.1370/afm.985
crossref pmid pmc

117. Kocalevent RD, Hinz A, Brähler E. 2013; Standardization of a screening instrument (PHQ-15) for somatization syndromes in the general population. BMC psychiatry. 13:1. 1–8. https://doi.org/10.1186/1471-244X-13-91
pmid pmc

118. Han C, Pae CU, Patkar AA, Masand PS, Kim KW, Joe SH, Jung IK. 2009; Psychometric properties of the Patient Health Questionnaire–15 (PHQ–15) for measuring the somatic symptoms of psychiatric outpatients. Psychosomatics. 50:6. 580–585. https://doi.org/10.1016/S0033-3182(09)70859-X
crossref pmid

119. Lee S, Huh Y, Kim J. 2014; Finding optimal cut off points of the Korean version of the Patient Health Questionnaire-9 (PHQ-9) for screening depressive disorders. Mood Emot. 12:1. 32–36.

120. Kyung Hee University Korean Medicine Hospital at Gangdong. 2020; Manual for doctors of Korean medicine at COVID-19 treatment sites.

121. Pfefferbaum B, North CS. 2020; Mental health and the Covid-19 pandemic. New England Journal of Medicine. 383:6. 510–512. https://doi.org/10.1056/NEJMp2008017
crossref pmid

122. Kwon JH, Kim JW, Park DG, Lee MS, Min SG, Kwon HI. 2008; Development and validation of the Hwa-Byung Scale. The Korean Journal of Clinical Psychology. 27:1. 237–252.

123. Lee Y, Baek Y, Park K, Jin HJ, Lee S. 2016; Development and validation of an instrument to measure the health status of healthy but unsatisfied people: Mibyeong index (未病 index). Journal of Society of Preventive Korean Medicine. 20:3. 45–53.

124. National Institute for Health and Care Excellence (NICE). 2014. Anxiety disorders Quality standard. NICE;Available from: www.nice.org.uk/guidance/qs53 Accessed March 26 2020.

125. National Institute for Health and Care Excellence (NICE). 2018. Posttraumatic stress disorder NICE guideline. NICE;Available from: www.nice.org.uk/guidance/ng116 Accessed March 26 2020.

126. Kwak HY, Hong SG, Kim JW. 2020; Research Trends in Mind-Body Intervention in the COVID-19 Pandemic. Korean Society for Meditation. 10:2. 53–71.

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