| 습부항의 산화 스트레스 및 인슐린 저항성 조절 효과에 대한 고찰 |
유인선1 
, 허준영1
, 조정효2
, 류호룡1
, 최정은1
, 박미소1,3
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1대전대학교 한의학과 심계내과학교실
2대전대학교 한의학과 간계내과학교실
3대전대학교 대전한방병원 임상시험센터 |
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| A Review of Wet Cupping’s Effects on Oxidative Stress and Insulin Resistance |
| Insun Yu1
, Junyoung Hur1
, Junghyo Cho2
, Horyong Yoo1
, Jungeun Choi1
, and Miso S. Park1,3
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1Department of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Daejeon University
2Department of Hepatology and Hematology of Korean Medicine, College of Korean Medicine, Daejeon University
3Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University |
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| Corresponding Author:
Jungeun Choi ,Tel: +82-42-470-9000, Fax: +82-42-477-9007, Email: satya01@naver.com |
| Corresponding Author:
Miso S. Park ,Tel: +82-42-470-9541, Fax: +82-42-470-9486, Email: miso.sophia.park@gmail.com |
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Received: April 15, 2025; Revised: May 19, 2025. Accepted: May 22, 2025. |
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| ABSTRACT |
Objectives: We investigated the potential mechanisms and preliminary clinical advantages of wet cupping therapy (WCT) in reducing oxidative stress and improving insulin resistance. Traditionally used in Eastern and Middle Eastern medicine to address blood stasis, WCT is now being explored for its broader metabolic and anti-inflammatory implications. The therapy involves skin incisions and negative pressure to remove blood, potentially eliminating oxidative metabolites (e.g., malondialdehyde) and inflammatory mediators while enhancing antioxidant defenses such as superoxide dismutase (SOD).
Methods: We selectively reviewed literature published within the past decade on physiological responses associated with WCT, with particular focus on oxidative stress markers, antioxidant enzyme activities, insulin sensitivity, and metabolic parameters. Additional evidence was examined from studies investigating improvements in microcirculation, immune modulation, and restoration of insulin signaling via the PI3K-Akt pathway.
Results: Preliminary findings suggest that WCT may contribute to reductions in fasting glucose, insulin resistance (HOMA-IR), and serum ferritin, indicating its potential as an adjunctive approach in managing chronic metabolic conditions such as type 2 diabetes and metabolic syndrome. Several studies report declines in oxidative stress markers (MDA, MPO) and increases in antioxidant enzymes (SOD, GPx, CAT). However, much of the current evidence stems from small-scale, short-term, or non-randomized studies, limiting the strength and generalizability of the conclusions.
Conclusions: WCT appears to offer preliminary metabolic benefits through oxidative stress reduction and insulin sensitivity enhancement. Nonetheless, well-designed randomized controlled trials and long-term studies are essential to confirm its clinical efficacy and establish standardized treatment protocols. |
| Keywords:
wet cupping | oxidative stress | insulin resistance | antioxidant system | metabolic syndrome |
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