A Case Report of Chronic Prostatitis/Chronic Pelvic Pain Syndrome(CP/CPPS) treated with Gyejibokryeong-hwan

Article information

J Korean Med. 2020;41(1):117-125
Publication date (electronic) : 2020 March 9
doi : https://doi.org/10.13048/jkm.20009
1Dept. of Korean Medicine, School of Korean Medicine, Pusan National University
2Dept. of Internal Medicine, Pusan National University Korean Medicine Hospital
3Clinical Research Center or Korean Medicine, Pusan National University Korean Medicine Hospital
Correspondence to: Seong Ha Park, School of Korean Medicine, Pusan National University, Mulgeum-eup, Yangsan-si, Gyeongsangnamdo, Rep. of Korea, Tel: +82-55-360-5944, Fax: +82-55-360-5509, E-mail: psh0680@hanmail.net
Received 2020 February 10; Revised 2020 February 27; Accepted 2020 February 28.

Abstract

Objectives

Chronic Prostatitis/Chronic Pelvic Pain Syndrome(CP/CPPS) is diagnosed on the basis of symptoms, principally pain or discomfort in the pelvic region. Pathophysiology and treatment of this disease has not been established. CP/CPPS’s main symptom appears to be an incurable pain and Collateral disease’s(絡病) symptoms also appear as incurable pain in general.

The purpose of this study is to report the clinical effects of Gyejibokryeong-hwan(桂枝茯苓丸) based on removing Stasis and freeing Collateral disease on CP/CPPS in which pain appears largely.

Methods

The patient was treated with Gyejibokryeong-hwan. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was used to assess treatment effect.

Results

NIH-CPSI and Pelvic pain decreased significantly after treatment.

Conclusions

Gyejibokryeong-hwan was effective in treating CP/CPPS. Especially, there was a clear effect on Pelvic pain among the symptoms.

Fig. 1

Subdomain Score of NIH-Chronic Prostatitis Symptom Index

Composition of Gyejibokryeong-hwan

Table 2

NIH-Chronic Prostatitis Symptom Index

Symptom and Total Score of NIH-Chronic Prostatitis Symptom Index

Pain Score of NIH-Chronic Prostatitis Symptom Index

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Article information Continued

Fig. 1

Subdomain Score of NIH-Chronic Prostatitis Symptom Index

Table 1

Composition of Gyejibokryeong-hwan

Herbal Name Pharmacogniostic Name A single Dose(mg)
桂枝 Cinnamomi Ramulus 500.0
茯笭 Hoelen 500.0
牧丹皮 Moutan Root Bark 500.0
芍藥 Peony Root 500.0
桃仁 Peach Kernel 500.0

Table 2

NIH-Chronic Prostatitis Symptom Index

Table 2

Table 3

Symptom and Total Score of NIH-Chronic Prostatitis Symptom Index

2018.10.30 2018.11.06 2018.12.04 2019.01.17 2019.01.31 2019.02.26
Symptom score 19 12 10 7 14 5
Total Score 30 17 15 11 22 8

Table 4

Pain Score of NIH-Chronic Prostatitis Symptom Index

2018.10.30 2018.11.06 2018.12.04 2019.01.17 2019.01.31 2019.02.26
Pain Localization
Perineal(Q1a) 1 0 0 0 1 0
Testicular (Q1b) 0 0 0 0 0 0
Tip of penis(Q1c) 0 0 0 0 0 0
Pubic area(Q1d) 0 0 0 0 0 0
Pain Symptom
Dysuria(Q2a) 0 0 0 0 0 0
Ejaculatory pain (Q2b) 1 0 0 0 0 0
Pain Quality
Pain Frequency(Q3) 5 2 2 1 3 1
Pain severity(Q4) 6 4 2 2 5 3
Herbal Medicine 1 dose tid 1 dose tid 1 dose tid 1 dose tid 1 dose tid 1 dose tid
Conventional Medicine (NSAID and antibiotics) + + +