Two Cases of Adult Atopic Dermatitis Improved by Administration of Osuyu-tang

Article information

J Korean Med. 2023;44(1):88-98

Publication date (electronic) : 2023 March 1

doi : https://doi.org/10.13048/jkm.23008

Ju-Hyun Lee ¹

, Sung-Gu Park ²

, Eun-Heui Jo ³^,⁴^,

, Min-Cheol Park ¹^,⁴^,

¹Department of Korean Medicine Ophthalmology, Otolaryngology and Dermatology, Wonkwang University Korean Medicine Hospital, Iksan, Jeollabuk-do, Republic of Korea

²Midas Korean Medicine Clinic, Seoul, Republic of Korea

³Department of Acupuncture and Moxibustion, Wonkwang University Korean Medicine Hospital, Deokjingu, Jeonju, Jeollabuk-do, Republic of Korea

⁴Research Center of Traditional Korean Medicine, Wonkwang University, Iksan, Jeollabuk-do, Republic of Korea

Correspondence to: Eun-Heui Jo, Department of Acupuncture & Moxibustion Medicine, Wonkwang University Korean Medicine Hospital 99, Garyeonsan-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54887, Republic of Korea, Tel: +82-63-270-1022, Fax: +82-63-270-1199; E-mail: freezo@wonkwang.ac.kr

Corresponding author: Min-Cheol Park, Department of Korean Medicine Ophthalmology, Otolaryngology and Dermatology, Wonkwang University, Korean Medicine Hospital, 895 Muwang-ro, Iksan-si, Jeollabuk-do, 54538, Republic of Korea, Tel: +82-63-859-2821, Fax: +82-63-841-0033, E-mail: spinx11@wonkwang.ac.kr

Received 2022 July 29; Revised 2022 August 24; Accepted 2023 February 14.

Abstract

Objectives

This study is to report two cases of adult atopic dermatitis improved by Osuyu-tang.

Methods

Osuyu-tang was prescribed to two adult atopic dermatitis patients. The patients took Osuyu-tang 3 times a day for 45 days and 50 days, respectively.

Results

In case 1 who complained of redness, erythema, edema, exudation, dryness, erosion, lichenification, scaly, and pruritus, skin symptoms improved from 15 to 2, and pruritus also improved from NRS 8 to 2. In case 2 who complained of redness-centered skin symptoms, skin symptoms improved from 15 to 1, and pruritus also improved from NRS 9 to 1.

Conclusions

When Osuyu-tang was prescribed to two patients with adult atopic dermatitis, significant improvement was observed. It is thought that Osyyu-tang can be used as the treatment of other similar diseases in the future.

Keywords: Case Report; Adult Atopic Dermatits; Korean Traditional Medicine; Osuyu-tang (Wuzhuyu-tang)

Fig. 1

Treatment Timeline

Fig. 2

Clinical Progress of Atopic Dermatitis

Fig. 3

Treatment Timeline

Fig. 4

Clinical Progress of Atopic Dermatitis

Table 1

Symptom Evaluation Index

Table 2

Prescription of Osuyu-tang (Wuzhuyu-tang)

Table 3

Systematic Examination

Table 5

Systematic Examination

Table 6

Symptom Progress of Atopic Dermatitis

References

1. Eichenfield LF, Tom WL, Chamlin SL, Feldman SR, Hanifin JM, Simpson EL, et al. 2014;Guidelines of care for the management of atopic dermatitis: Section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol 70(2):338–51. https://doi.org/10.1016/j.jaad.2013.10.010 .

2. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. 1980;Acta Derm Venereol 92:44–7. https://doi.org/10.2340/00015555924447 .

3. Rho EJ. 2018. Gobangyuchwi Seoul: Barun Herbal Medicine. p. 771–8.

4. Carroll CL, Balkrishnan R, Feldman SR, Fieischer AB, Manuel JC. 2005;The burden of atopic dermatitis: Impact on the patient, family, and society. Pediatr Dermatol 22(3):192–9. https://doi.org/10.1111/j.1525-1470.2005.22303.x .

5. Ellis CN, Mancini AJ, Paller AS, Simpson EL, Eichenfield LF. 2012;Understanding and managing atopic dermatitis in adult patients. Semin Cutan Med Surg 31(3):S18–22. https://doi.org/10.1016/j.sder.2012.07.006 .

6. Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. 2018;Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol 32(5):657–782. https://doi.org/10.1111/jdv.14891 .

7. Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. 2018;Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. J Eur Acad Dermatol Venereol 32(6):850–78. https://doi.org/10.1111/jdv.14888 .

8. Abraham A, Roga G. 2014;Topical steroid -damaged skin. Indian J Dermatol 59(5):456–9. https://doi.org/10.4103/0019-5154.139872 .

9. Rho EJ. 2018. Gobangyuchwi Seoul: Barun Herbal Medicine. p. 771–8.

10. European Task Force on Atopic Dermatitis. 1993;Severity scoring of atopic dermatitis: the SCORAD index. Dermatology 186:23–31. https://doi.org/10.1159/000247298 .

11. College of Korean Medicine Dermatology & Surgery Textbook Compilation Committee. 2007. Text of Traditional Korean Dermatology & Surgery Pusan: Sunwoo. p. 355–61.

12. Son JS, Choi IH. 2001;A case of atopic dermatitis. J Korean Oriental Med 22(4):151–7.

13. Lim WK, Sun YJ, Ock MG, Kim CH, Back SH. 2004;A clinical case of severe atopic dermatitis. J Korean Med Ophthalmol Otolaryngol Dermatol 17(3):114–9.

14. Korea Centers for Disease Control and Prevention. Atopic dermatitis doctor diagnosis experience rate Korea Centers for Disease Control and Prevention [serial online]; 2020. [Cited 2022 August 23]. Available from: URL:https://index.go.kr/potal/main/EachDtlPageDetail.do?idx_cd=1438 .

15. Ju YS. 2013. Jeungbo Ungok Herbology Wanju: Wooseok. p. 783–8.

16. Ryu MJ. 2014;Functional activities of Evodia officinalis extract as cosmetic materials. Kor J Aesthet Cosmetol 12(6):797–804.

17. Jeon SA, Noh HM, Jo EH, Park MC. 2017;Antibiotic, antioxidant and whitening effects of Jwa Kum-Whan and Soo Ryeon-Whan. J Korean Med Ophthalmol Otolaryngol Dermatol 30(2):100–11. https://doi.org/10.6114/JKOOD.2017.30.2.100 .

18. Lee SJ, Seo HA, Lee SI. 2016;A case report of psoriasis treated by Osuyu-tang based on Shanghanlun. Herb Formula Sci 24(1):53–61. https://doi.org/10.14374/HFS.2016.24.1.53 .

19. Lim EK, Jeong JW. 2020;A case of nummular eczema treated by Osuyu-tang based on Shanghanlun provisions. J of KMediACS 12(1):147–57. https://doi.org/10.22891/KMEDIA.2020.12.1.147 .

20. Yun HJ, Heo SK, Lee YT, Park WH, Park SD. 2008;Anti-inflammatory effect of Evodia Officinalis DODE in mouse macrophage and human vascular endotherial cells. Kor J Herbol 23(1):29–38.

21. Lee YS, Lee GH, Park JH, Kwon YK, Shin SW. 2007;Water extracted Evodiae Fructus possesses immunomodulatory activities on cyclophosphamide induced immunesuppression. J Physiol & Pathol Korean Med 21(1):1450–5.

Article information Continued

Fig. 2

Clinical Progress of Atopic Dermatitis

Fig. 4

Clinical Progress of Atopic Dermatitis

Table 1

Symptom Evaluation Index

		Symptom Severity
Objective Symptoms	Redness Swelling Oozing Dryness Excoriation Lichenification Scale	0=Absence 1=Mild 2=Moderate 3=Severe
Subjective Symptoms	Pruritus Sleep Loss	0 (None) ~ 10 (Severe)

Table 2

Prescription of Osuyu-tang (Wuzhuyu-tang)

	Name of Natural Medicine (Herbal Medicine)	Weight(g)
吳茱萸	Tetradium ruticarpum (A. Juss.) T.G. Hartley	3
生薑	Zingiber officinale Roscoe	6
大棗	Ziziphus jujuba var. inermis (Bunge) Rehder	4
人蔘	Panax ginseng C.A. Mey.	3

	Total Amount	16

Table 3

Systematic Examination

大便	대변을 하루 1번 정도 시원하게 본다.
小便	소변을 시원하게 잘 본다.
寒熱	더위를 못 참는다. 얼굴에서 열이 나는 것 같다. 손발이 차갑다.
汗出	땀이 잘 나지 않는다. 사우나 가거나 운동할 때만 땀이 난다.
食慾	입맛이 좋다. 골고루 잘 먹는다. 요즘 살이 빠지고 있다.
消化	소화가 잘 된다. 배에서 소리가 자주 난다.
睡眠	잠을 잘 잔다. 잠이 많은 편이다. 할 일이 있어도 체력이 받쳐주지 않는다.
口渴	생수, 차, 음료수, 우유, 커피 다 포함해서 하루에 1ℓ 가량의 액체를 마신다.
頭部	피곤하거나 신경 쓰면 몸 어딘가가 자주 떨린다.
皮膚	피부가 잘 빨개진다. 피부가 건조하다.

Table 5

Systematic Examination

大便	하루 1–2번 정도 대변을 본다. 하루라도 변을 보지 못하면 무척 불편하다. 변을 보고 난 후 어딘가 모르게 시원하지 않다. 변이 굳다. 아랫배에 가스가 잘 찬다.
小便	소변을 시원하게 잘 본다.
寒熱	추위를 못 참는다. 더위를 못 참는다. 손발이 차갑다.
汗出	땀이 잘 나지 않는다. 사우나 가거나 운동할 때만 땀이 난다. 가슴, 겨드랑이에만 땀이 난다.
食慾	입맛이 좋다. 음식을 잘 먹는다.
消化	속이 자주 쓰리다. 배가 자주 아프다. 트림을 자주 한다.
睡眠	잠을 잘 자지 못한다. 자다가 자주 깨어난다.
口渴	따뜻한 물이 좋다. 생수, 차, 음료수, 우유, 커피 다 포함해서 하루에 1.5ℓ 가량의 액체를 마신다.
胸部	목-가슴이 조이는 옷은 답답해서 싫다.
皮膚	피부 트러블이 잘 생긴다. 피부가 건조하다.
頭面	목에 무언가 걸려있는 느낌이 들 때가 자주 있다.

Table 6

Symptom Progress of Atopic Dermatitis

		2017.03.30	2017.05.25	2017.08.09
Subjective Symptoms	Redness	3	1	1
	Swelling	1	1	0
	Oozing	2	1	0
	Dryness	3	1	0
	Excoriation	2	1	0
	Lichenification	2	1	0
	Scale	2	1	0

Objective Symptoms	Pruritus	9	4	1
Objective Symptoms	Sleep Loss	8	3	1

Total		32	14	3