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J Korean Med. 2013;34(1): 1-14.
The Effects of Platycodi Radix on Obese Type 2 Diabetes Mouse Model Induced by High Fat, High Carbohydrate Diet
Oh-Jun Kwon, Seung-Wook Lee, Sun-Ho Paik, Su-Ryun Han, Young-Min Ahn, Se-Young Ahn, and Byung-Cheol Lee
Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University
Corresponding Author: Byung-Cheol Lee ,Tel: +82-2-958-9182, Fax: +82-2-958-9158, Email: hydrolee@korea.com
Received: May 4, 2012;  Accepted: September 12, 2012.
Objectives: This study was designed to investigate the anti-obesity, anti-diabetic and anti-inflammatory effects of Platycodi radix on obese type 2 diabetes mouse model. Methods: Obese type 2 diabetes mouse model was induced by Surwit's high fat, high sucrose diet for 8 weeks. Models were divided into 4 groups of normal diet (ND, n=10), high fat and high sucrose diet (HFD, n=10), high fat and high sucrose diet with Platycodi radix (PR, n=10), and high fat and high sucrose diet with Metformin (Met, n=10). Body weights were measured every week. After 7 weeks fasting, blood sugar and oral glucose tolerance tests were conducted. After 8 weeks blood samples were taken from mouse hearts and analyzed biochemically. Lipid profile, fructosamine, leptin and weight of epididymal fat pad and liver were measured. Adipose tissue macrophage percentage was analyzed by fluorescence-activated cell sorting (FACS). Results: Compared with the HFD group, body weight, glucose level, fructosamine, weight of epididymal fat pad and adipose tissue macrophage percentage decreased in the PR group. Conclusions: These results suggest that Platycodi Radix has anti-obesity, anti-diabetic, and anti-inflammatory effects on obese type 2 diabetes mouse model.
Keywords: Platycodi radix | Type 2 Diabetes | Obesity | Inflammation | Insulin resistance
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