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ORIGINAL ARTICLE
J Korean Med. 2013;34(1): 89-102.
Effects of Root of Curcumin longa on LPS-induced Lung Injury
Ji-Seok 1, Su-Young Yang1, Min-Hee Kim2, Uk Namgung2, and Yang-Chun Park1
1Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University
2Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University
Corresponding Author: Yang-Chun Park ,Tel: +82-42-229-6919, Fax: +82-42-254-3403, Email: omdpyc@dju.kr
Received: August 17, 2012;  Accepted: October 31, 2012.
ABSTRACT
Objectives: This study aimed to evaluate the effects of root of Curcumin longa (RCL) on LPS-induced COPD (chronic obstructive pulmonary disease) model.
Materials and Methods: Extract of RCL was treated to RAW 264.7 cells and LPS-induced COPD mouse model. Then, various parameters such as cell-based protective activity, airflow limitation, accumulation of immune cells and histopathological finding were analyzed.
Results: RCL showed a protective effect on LPS-induced cytotoxicity in RAW 264.7 cells. RCL treatment also revealed a protective effect on LPS-induced lung injury in a COPD mouse model. This effect was demonstrated via the reduction of accumulation of immune cells and pathophysiological regulation of caspase 3, elastin and collagen in lung tissue.
Conclusions: These data suggest that RCL has a pharmaceutical property on lung injury. This study provides scientific evidence for the efficacy of RCL for clinical application to COPD patients.
Keywords: Root of Curcumin longa | chronic obstructive pulmonary disease | emphysema | RAW 264.7 cells
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