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JKM > Volume 44(3); 2023 > Article
Kwon: Trends in research on the efficacy of herbal medicines for particular matter-induced asthma focused on Pubmed



This study aimed to review the experimental research trends in asthma caused by particulate matter to conduct further researches, especially in clinical trials.


We searched for the meaningful literature using medicinal herb for asthma through the Pubmed databases.


Finally, six studies were finally selected. These studies showed recent trends, from 2018 to 2021 and conducted mostly in South Korea. The type of fine dust and the method of inducing asthma are different for each paper, but the effective mechanism is relatively common. It was commonly confirmed that the ratio and number of eosinophils, th2 cells and related cytokines are decreased in BALF and lung tissue by administration of medicinal herb.


Although the method of inducing asthma using fine dust has not yet been standardized, it is thought that more meaningful evaluation results can be derived if a standardized animal model is established in the future. Nevertheless, based on the results that herbal medicine is effective for particular matter induced asthma, it is expected that it will be the basis for expanding into future clinical studies.

Fig. 1
Prisma flow diagram of study selection process for this systematic review
Table 1
Search strategy for MEDLINE
Number Search terms
1 Fine Dust
2 Particulate Matter*
3 OR #1-2
4 herbal medicine[MeSH Terms]
5 drugs, chinese herbal[MeSH Terms]
6 medicine, kampo[MeSH Terms]
7 medicine, korean traditional[MeSH Terms]
8 ethnopharmacology[MeSH Terms]
9 herbal medicine
10 medicinal plant*
11 traditional medicine
12 phytomedicine
13 herbal drug*
14 herbal preparation*
15 herbs medicinal
16 herb medicine
17 plants extracts
18 plants, medicinal
19 Chinese medicine
20 decoction
21 OR #4-20
21 #3 AND #21


1. Lee MY, Seo CS, Lee JA, Lee NH, Kim JH, Ha HK, et al. 2011; Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflamamtion via upregulation of heme oxygenase-1. Food and Chemical Toxicology. 49:4. 829–837.
crossref pmid

2. Funaguchi N, Ohno Y, La BLB, Asai T, Yuhgetsu H, Sawada M, et al. 2007; Narirutin inhibits airway inflamamtion in an allergic mouse model. Clinical and Experimental Pharmacology and Physiology. 34:776–770.

3. Fahy JV. 2015; Type2 inflammation in ahstma-present in most, absent in many. Nature reviews immonolgy. 15:57–65.

4. Walsh ER, Sahu N, Kearley J, Benjamin E, Kang BH, Humbles A, et al. 2008; Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma. Journal of Experimental Medicine. 205:6. 1285–1292.
pmid pmc

5. Lee H, Myung WJ, Kim SE, Kim DK, Kim H. 2018; Ambient air pollution and completed suicide in 26 South Korean cities: Effect modification by demographic and socioeconomic factors. Science of The Total Environment. 639:944–951.
crossref pmid

6. Basith S, Manavalan B, Shin TH, Park CB, Lee WS, Kim JT, et al. 2022; The Impact of Fine Particulate Matter 2.5 on the Cardiovascular System: A review of the Invisible Killer. Nanomaterials. 12:1–28.
crossref pmid pmc

7. Schraufnagel DE. 2020; The health effects of ultrafine particels. Experimental & Molecular Medicine. 52:311–317.

8. Lyu YR, Kim JH, Yang WK, Kim SH, Park YC. 2019; Clinical Research Trends in Respiratory Diseases Related to Particular Matter. Journal of Korean Internal Medicine. 40:3. 443–457.

9. Kwon BI, Kim TW, Shin K, Kim YH, Yuk CM, Shin DM, et al. 2017; Enhanced Th2 cell differentiation and function in the absence of Nox2. Allergy. 72:2. 252–265.

10. Seo YS, Kim HS, Lee AY, Chun JM, Kim SB, Moon BC, et al. 2019; Codonopsis lanceolata attenuates allergic lung inflamamtion by inhibiting Th2 cell activation and augmenting mitochonrial ROS dismutase(SOD2) expression. Scientific reports. 9:2312 https://doi.org/10.1038/s41598-019-38782-6
pmid pmc

11. World Health Organization. General guidelines for methodologies on research and evaluation of traditional medicine. WHO/EDM.TRM/200.1. https://apps.who.int/iris/handle/10665/66783

12. Jung SY, Park JK, Pakr JW, Jo H, Seo CS, Jeon WY, et al. 2020; Sojadodamgangki-tang attenuates allergic lung inflamamtion by inhibiting T helper 2 cells and Augmenting alveolar macrophages. Journal of Ethnopharmacology. 263 https://doi.org/10.1016/j.jep.2020.113152

13. Shefrin AE, Goldman R.D2009; Use of dexamethasone and prednisone in acute asthma exacerbations in pediatric patients. Canadian family physician. 55:704–706.
pmid pmc

14. Ray A, Khare A, Krishnamoorthy N, Qi Z, Ray P, Wang CZ. 2010; Regulatory T cells in many flavors control asthma. Mucosal Immunology. 3:3. 216–229.
pmid pmc

15. Theofani E, Semitekilou M, Morianos I, Samitas K, Xanthou G. 2019; Targeting NLRP3 Inflammasome Activation in Severe Asthma. Journal of Clinical Medicine. 28:161510.3390/jcm8101615
crossref pmid pmc

16. Xie Y, Abel PW, Casale TB, Tu Y. 2022; TH17 cells and corticosteroid insensitivity in severe asthma. The Journal of Allergy and Clinical Immunology. 149:2. 467–479.

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