Home | Register | Login | Inquiries | Alerts | Sitemap |  

Advanced Search
JKM > Volume 41(1); 2020 > Article
Lee, Lee, Hong, Yun, and Park: A Case Report of Chronic Prostatitis/Chronic Pelvic Pain Syndrome(CP/CPPS) treated with Gyejibokryeong-hwan



Chronic Prostatitis/Chronic Pelvic Pain Syndrome(CP/CPPS) is diagnosed on the basis of symptoms, principally pain or discomfort in the pelvic region. Pathophysiology and treatment of this disease has not been established. CP/CPPS’s main symptom appears to be an incurable pain and Collateral disease’s(絡病) symptoms also appear as incurable pain in general.
The purpose of this study is to report the clinical effects of Gyejibokryeong-hwan(桂枝茯苓丸) based on removing Stasis and freeing Collateral disease on CP/CPPS in which pain appears largely.


The patient was treated with Gyejibokryeong-hwan. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was used to assess treatment effect.


NIH-CPSI and Pelvic pain decreased significantly after treatment.


Gyejibokryeong-hwan was effective in treating CP/CPPS. Especially, there was a clear effect on Pelvic pain among the symptoms.

Fig. 1
Subdomain Score of NIH-Chronic Prostatitis Symptom Index
Table 1
Composition of Gyejibokryeong-hwan
Herbal Name Pharmacogniostic Name A single Dose(mg)
桂枝 Cinnamomi Ramulus 500.0
茯笭 Hoelen 500.0
牧丹皮 Moutan Root Bark 500.0
芍藥 Peony Root 500.0
桃仁 Peach Kernel 500.0
Table 2
NIH-Chronic Prostatitis Symptom Index
Table 3
Symptom and Total Score of NIH-Chronic Prostatitis Symptom Index
2018.10.30 2018.11.06 2018.12.04 2019.01.17 2019.01.31 2019.02.26
Symptom score 19 12 10 7 14 5
Total Score 30 17 15 11 22 8
Table 4
Pain Score of NIH-Chronic Prostatitis Symptom Index
2018.10.30 2018.11.06 2018.12.04 2019.01.17 2019.01.31 2019.02.26
Pain Localization
Perineal(Q1a) 1 0 0 0 1 0
Testicular (Q1b) 0 0 0 0 0 0
Tip of penis(Q1c) 0 0 0 0 0 0
Pubic area(Q1d) 0 0 0 0 0 0
Pain Symptom
Dysuria(Q2a) 0 0 0 0 0 0
Ejaculatory pain (Q2b) 1 0 0 0 0 0
Pain Quality
Pain Frequency(Q3) 5 2 2 1 3 1
Pain severity(Q4) 6 4 2 2 5 3
Herbal Medicine 1 dose tid 1 dose tid 1 dose tid 1 dose tid 1 dose tid 1 dose tid
Conventional Medicine (NSAID and antibiotics) + + +


1. Kim HJ. Therapeutic Options for Chronic Prostatitis/Chronic Pelvic Pain Syndrome. J Korean Continence Soc. 2007; 11:1–8.

2. Mo XW, Wang B, Li HS, Dang J, Hang L. The Scheme and Method of TCM in Treating CP. World Chinese Medicine. 2013; 8:10. 1244–7.

3. Wang Q, Zhang JX. Clinical Research Progress of Guizhifulingwan in the Treatment of Andrology. Journal of New Chinese Medicine. 2010; 42:10. 105–6.

4. Litwin MS, McNaughton-Collins M, Fowler FJ, Nickel JC, Calhoun EA, Pontari MA, et al. The National Institutes of health chronic prostatitis symptom index: development and validation of a new outcome measure. Chronic Prostatitis Collaborative Research Network. J Urol. 1999; 162:2. 369–75.
crossref pmid

5. Choi JY, Lee MJ, Cho SH, Kim SB, Lee ST, Min SK. Comparison of Clinical Symptoms Scored According to NIH-CPSI in Patients with Chronic Prostatitis Syndrome Category IIIa and IIIb. Korean J UTII. 2011; 6:1. 42–7.

6. Kim HJ, Hong JH. Efficacy of Propiverine for Chronic Prostatitis/Chronic Pelvic Pain Syndrome. J Korean Continence Soc. 2008; 12:2. 158–62.

7. National Administration of Traditional Chinese Medicine. Guidelines for Diagnosis and Treatment of Common Internal Diseases in Chinese Medicine Symptoms in Chinese Medicine. Nanjing University Press;1994. p. 698

8. Kim JT, Kim HD, Park JS, Lee JH, Kim SY, Choi JY, et al. Study on Guideline for the Treatment of Chronic Prostatitis in Korean Medicine - Search Chinese Traditional Medical Papers from 2003~2013. Korean J Oriental Physiology & Pathology. 2014; 28:3. 271–9.

9. Li HS, Han FL, Li WI. Study on Relationship of common traditional Chinese medicine syndromes in 918 cases of Chronic Prostatitis (CP). Beijing Journal of Traditional Chinese Medicine. 2008; 27:6. 416–8.

10. Han LA, Wang B, Li HS. Treatment of chronic prostatitis according to the blood stasis theoretics of traditional Chinese medicine. Global Traditional Chinese Medicine. 2012; 5:7. 488–91.

11. Zheng XD, Yan HF. Research Progress of Meridian and Collateral Disease in Recent 20 Years and Application Research Progress in Cardiac Disease. Yunnan Journal of Traditional Chinese Medicine and Materia Medica. 2015; 36:12. 89–93.

12. Ge HN. Collateral Disease Theory of Yetianshi and its application on Miscellaneous Diseases due to internal injury. J Nanjing University TCM. 2016; 32:5. 409–12.

13. LI H, SUN ZX. Clinical Research of Guizhifulingwan Decoction and Acupuncture in Treatment on Patients With Prostatitis III. Liaoning Journal of Traditional Chinese Medicine. 2011; 38:8. 1557–60.

14. Yu JS. New Clinical Application of Guizhi Fuling Pill. Clinical Journal of Traditional Chinese Medicine. 2006; 18:6. 606

15. Ministry of Food and Drug Safety. Drug Integration Information System. (cited Jan 25, 2020). Available from: URL: http://https://nedrug.mfds.go.kr/searchDrug?sort=&sortOrder=false&searchYn=true&page=1&searchDivision=detail&itemName=%EA%B3%84%EC%A7%80%EB%B3%B5%EB%A0%B9%ED%99%98&entpName=&ingrName1=&ingrName2=&ingrName3=&itemSeq=&stdrCodeName=&atcCodeName=&indutyClassCode=&sClassNo=&narcoticKindCode=&etcOtcCode=&makeMaterialGb=&searchConEe=AND&eeDocData=&searchConUd=AND&udDocData=&searchConNb=AND&nbDocData=&startPermitDate=&endPermitDate=#
pmid pmc

16. Lee PR, Ahn GS, Choi SH. Study on the Effects of Guizhifulingwan and Its Components on Dextran-Induced Blood Stasis and HA-Induced Elevated Blood Viscosity Models. The Kyung Hee University Oriental Medical Journal. 1997; 19:2. 39–67.

17. Jo HG, Park AR, Kee YB, Kang DH, Choi JB, Sul JU. A Clinical Trial on the Blood Stasis and Efficacy of Kyejibokryong-whan (Guizhifuling-wan) in the Patients with Motor Vehicle Accident. J Oriental Rehab Med. 2011; 21:3. 45–55.

18. Choi GY, Cho JH, Jang JB, Lee KS. Clinical Study on the Efficacy of Gyejibokryeong-hwan in the Treatment of Menorrhalgia. J Korean Obstet Gynecol. 2004; 17:1. 178–86.

19. Ma Y. New clinical experience of Guizhifuling-wan. CJITWN. 2010; 11:8. 726–7.

20. Wagenlehner FM, Oliver van Till JW, Magri V, Perletti G, Houbiers JG, Weidner W, et al. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) symptom evaluation in multinational cohorts of patients with chronic prostatitis/chronic pelvic pain syndrome. Eur Urol. 2013; May. 63:5. 953–9.
crossref pmid

21. Cho IR. Text Book of Andrology. Seoul: Koonja;2004. p. 571

Editorial office contact information
3F, #26-27 Gayang-dong, Gangseo-gu Seoul, 157-200 Seoul, Korea
The Society of Korean Medicine
Tel : +82-2-2658-3627   Fax : +82-2-2658-3631   E-mail : skom1953.journal@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Developed in M2PI